Moore et al, The rapid emergence of small molecule #RNA modulator hit discovery: unlocking the potential | Expert Opinion on #DrugDiscovery 2026 | #MedChem #DrugDesign #Free2Read #chemsky 🧪 doi.org/10.1080/1746...

🎨 Ready to turn your research into a visual story?
The #GraphicalAbstractCompetition2026 is here! Showcase your science creatively and put your research communication skills to the test. 🧪✨
👉 All details here: qrr.to/f76483b7
#MedChem #ChemBio

Take a look in our latest issue at research by Kanaka Hettiarachchi & co. describing an integrated platform for accelerating therapeutic macrocyclic peptide purification in high-throughput medicinal chemistry #medchem

📍Merck & Co.
doi.org/10.1039/d6md...

🔓Don't miss this #OpenAccess review in our latest issue from Herman O. Sintim & co. @notredame.bsky.social revisiting multicomponent Doebner and Povarov quinoline synthesis for modern-day drug-discovery #orgchem #medchem

Check out the full article here👇
doi.org/10.1039/d6ob...

🧪 One clear trend across 12 approved drugs: safer #fluorination.
This review examines 12 FDA-approved CF2-containing drugs (2016–2025), mapping industrial routes toward safer fluorination.
➡️ https://tinyurl.com/46wdmfck
#FluorineChemistry #ProcessChemistry #DrugDiscovery #MedChem #BJOC 💎🔓

except that in #MedChem there is no real "answer", and the physicochemical properties will just keep improving after many rounds of optimisation

2/2

A most excellent molecule (and chemist) with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

Be sure to read a review from Zahoor Ahmad et al. at CSIR-IIIM in our latest issue looking at strategies for designing polypharmacological agents against multi-drug-resistant tuberculosis #medchem

Find the full article on our website🔽
doi.org/10.1039/d6md...

Back from #NMMC30 in Messina with valuable feedback on our graph-based molecular similarity approach, ideas for further validation, and opportunities for #MedChem and #DrugDiscovery applications. Thanks @socchimita.bsky.social for a stimulating meeting, and a wonderful excursion to Taormina!

📢Our latest issue is now online!

🔓Check out the #OpenAccess review behind the cover by Harshita Kumari & co. from the University of Cincinnati discussing macrocycle-mediated modulation and repurposing of antibacterial and non-antibacterial drugs #orgchem #medchem

doi.org/10.1039/d6ob...

🔓Don't miss #OpenAccess research by Elena Cichero & co. from University of Genoa probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays #medchem

Check it out in full below👇
doi.org/10.1039/d6md...

Check out research in our latest issue from Qidong You, Lei Wang et al. at China Pharmaceutical University reporting the discovery of DDO-4279 as a PP5 degrader for the treatment of obesity #medchem

Read the full paper here🔽
doi.org/10.1039/d6md...

Working on molecular similarity or virtual screening? I’d love to hear your perspective — let’s discuss it in Messina!

#MedChem #CompChem #CompChemSky #DrugDiscovery

Good #medchem example of targeting pseudokinases to #allosteric-ally regulate #PPI / #kinase activity. Reassuring is decent kinome selectivity despite targeting the ATP-binding site, and would love to see further development of C160 covalent activators.

www.cell.com/cell-chemica...

A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...

Take a look at this Opinion article by Matthew W. D. Perry & Rhona J. Cox in our latest issue describing a game to communicate the iterative optimisation of multiple parameters in medicinal chemistry to wider audiences #medchem

📍 @astra-zeneca.bsky.social
doi.org/10.1039/d6md...

Be sure to read in our latest issue a paper from Héctor R. Morbidoni, Guillermo R. Labadie & co. at IQUIR-CONICET exploring the antimycobacterial profile of N-alkyl imidazoles #medchem

Find it in full on our website🔽
doi.org/10.1039/d6md...

📜 Beatriz García Bell presentó el póster 'Synthesis of Polyfunctionalized Cyclopentitols: a Study of 2,2-gem-difluorinated Carbohydrates'

👏 Gracias a Grupo Especializado de Hidratos de Carbono de la RSEQ por reunir a la comunidad científica

#Glycotime #QuimicaOrganica #MedChem #Sevilla

Don't miss this research by Bahaa G. M. Youssif et al. from Assiut University in our latest issue developing a series of novel methylene disalicylic acid derivatives targeting DNA gyrase and topoisomerase IV #medchem

Check out their full report below👇
doi.org/10.1039/d6md...

🔓Be sure to read this #OpenAccess paper by Omar Boutureira, Yolanda Díaz, M. Isabel Matheu et al. from @urv.cat in our latest issue describing stereoselective access to allenic sphingosine analogues as SphK inhibitors #orgchem #medchem

Find it in full on our website👇
doi.org/10.1039/d6ob...