(BioRxiv All) Functional validation and characterization of Slc39a8 genotype effects on ethanol consumption and related phenotypes: Alcohol use disorders are heritable, and large-scale genome-wide association studies have recently identified novel genetic loci that are… #BioRxiv #MassSpecRSS

(BioRxiv All) Protocol for Single-Cell Patch-Proteomics: identify specific proteins associated with electrophysiological properties from individual neurons: Single-cell patch-proteomics is a novel and powerful technique combining electrophysiological and quantitative proteomic… #BioRxiv #MassSpecRSS

(BioRxiv All) Native Mass Spectrometry Reveals Distinct Effects of Linker Length and Targeting-Ligand Identity on PROTAC Ternary Complexes: Proteolysis-targeting chimeras (PROTACs) promote targeted protein degradation by inducing a transient ternary complex between a protein… #BioRxiv #MassSpecRSS

(BioRxiv All) Novel Replication Stress-Associated High-Grade Serous Ovarian Cancer Models Recapitulate Diverse Tumour Ecosystems and Enable Preclinical Studies: Abstract Background: High-grade serous ovarian cancer (HGSC) is characterized by extensive genomic heterogeneity and… #BioRxiv #MassSpecRSS

(BioRxiv All) Global mapping of protein localization in vegetative Dictyostelium discoideum by subcellular spatial proteomics: Dictyostelium discoideum is a genetically tractable amoebozoan model organism widely used to study conserved eukaryotic cellular processes, yet a… #BioRxiv #MassSpecRSS

(BioRxiv All) Beyond Structure: Protein and Solution Dynamics Shape Ligand-BindingThermodynamics: Variable-temperature electrospray ionization native mass spectrometry (vT-ESI nMS) provides a means to determine how temperature-dependent changes in protein and solution dynamics… #BioRxiv #MassSpecRSS

(BioRxiv All) Programmable sequence-resolved in situ profiling of glycoRNA-protein interactomes by GlycoRNA-Map: Cell-surface glycoRNAs participate in diverse biological processes, but they were investigated as pooled populations and the protein interactome of individual… #BioRxiv #MassSpecRSS

(BioRxiv All) Novel protein networks in motile cilia from human epithelial cells revealed by cryo-ET and proteomics analysis of cilia from PCD patients: In our past study on human cilia from primary ciliary dyskinesia (PCD) patients using cryo-electron tomography and mass… #BioRxiv #MassSpecRSS

Did you know that @biorxiv-medrxiv.bsky.social posts weekly to share updates and features that can help you make the most out of your preprint? Follow us there to learn how to leverage preprints to their fullest potential. #preprints #openscience #openrxiv #biorxiv #medrxiv

(BioRxiv All) A meiotic B-type cyclin selectively drives mitotic progression and fidelity in cancer cells: Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type… #BioRxiv #MassSpecRSS

(BioRxiv All) Enabling subcellular DESI-MSI for broad adoption: Acquisition, analysis, and application: Subcellular mass spectrometry imaging (MSI) has required specialized instrumentation and approaches. Additionally, data analysis has required expensive proprietary software,… #BioRxiv #MassSpecRSS

One of my PhD chapters is now available as a preprint on #bioRxiv! Are you interested in #singlecell? Do you want to know more about #social #behaviour? Go and check out how we resolved the first telencephalon atlas of the highly social interacting cleaner wrasse fish.

(BioRxiv All) Mutanome-guided immunopeptidomics of blood plasma for neoepitope detection in solid tumors is constrained by cfDNA variant calling sensitivity and MS detection limits: Introduction: Neoepitopes form the basis of tumor-specific immune responses. Tissue biopsy, the… #BioRxiv #MassSpecRSS

(BioRxiv All) Mapping virulence-associated protein interaction networks reveals regulators of thermotolerance in Cryptococcus neoformans: Protein-protein interactions (PPIs) influence critical biological processes in pathogenic microorganisms, such as the human fungal… #BioRxiv #MassSpecRSS

(BioRxiv All) Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome: Neural organoids represent a promising approach for modelling neural circuits and neurological disease, yet their utility depends on whether they can recapitulate the molecular complexity of… #BioRxiv #MassSpecRSS

(BioRxiv All) Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.: Clostridioides difficile infection (CDI) is characterized by toxin-mediated epithelial injury, intestinal inflammation, and a high frequency of… #BioRxiv #MassSpecRSS

(BioRxiv All) Forsythoside B attenuates neuropathic pain by suppressing USP7/HIF-1α-mediated microglial glycolytic reprogramming: Neuropathic pain involves spinal microglial activation and metabolic changes.Forsythoside B (FB) has anti-inflammatory effects, but its role in… #BioRxiv #MassSpecRSS

(BioRxiv All) Translation fidelity mechanisms and their changes in aging: Protein errors (amino acid misincorporations) are associated to protein misfolding and misfunction, and lower levels correlate with longer lifespan. Despite their prevalence, proteome-wide tracking of… #BioRxiv #MassSpecRSS

(BioRxiv All) Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation: Early embryogenesis relies extensively on maternally deposited products until zygotic genome activation, yet the dynamics for the synthesis of new… #BioRxiv #MassSpecRSS

(BioRxiv All) Relative humidity differentially modulates decay of structurally distinct respiratory viruses in deposited human saliva particles: Respiratory viruses pose a major threat to human health. Environmental virus persistence in respiratory secretions is essential for… #BioRxiv #MassSpecRSS