(BioRxiv All) Proteomic Characterization of Prostate Cancer Bone Metastasis Subtypes Defines Progressive Remodeling States of the Bone-Tumor Microenvironment: Prostate cancer (PC) bone metastases (PCBM) are a debilitating disease morbidity that primarily affects the axial… #BioRxiv #MassSpecRSS

(BioRxiv All) Pharmacokinetic properties of Ogerin and its regulation of post-ischemia signaling in mice: Ogerin, a positive regulator of GPR68, reduces infarct volume and attenuates blood-brain barrier (BBB) leakage post transient middle cerebral artery occlusion (tMCAO).… #BioRxiv #MassSpecRSS

(BioRxiv All) Pannexin 1 Ablation Disrupts Cell Cycle Progression and Compromises the Structure of Melanoma Tumours: Pannexin 1 (PANX1) is a channel-forming glycoprotein that has been implicated in regulating melanoma cell properties such as growth, migration, and invasion.… #BioRxiv #MassSpecRSS

(BioRxiv All) ATP synthase deficiency promotes prolonged hydrogenproduction in Chlamydomonas: Photosynthetic electron transport is tightly regulated to balance ATP and NADPH production and prevent over-reduction of the photosynthetic machinery. How this balance is maintained… #BioRxiv #MassSpecRSS

(BioRxiv All) mzQC: a versatile way to communicate quality information for biological mass spectrometry: Reliable quality control (QC) is essential for reproducible biological mass spectrometry, yet QC information is still typically stored in tool-specific, poorly… #BioRxiv #MassSpecRSS

(BioRxiv All) Sex-Dependent Microbiome-Metabolome Remodeling Associated with Bacteroides acidifaciens Modulation of Acute Respiratory Distress Syndrome: Acute respiratory distress syndrome (ARDS) is a severe lung disorder influenced by the interplay between the intestinal… #BioRxiv #MassSpecRSS

(BioRxiv All) digimouth: a Python package for modeling aroma release in food science: The modeling of aroma release in food science is a complex, multidisciplinary field integrating mass transfer theory and principles of physical chemistry. While mechanistic models have long… #BioRxiv #MassSpecRSS

(BioRxiv All) IgG4 antibody repertoire diversity is stable over several years in health and autoimmune disease: Despite its relative anti-inflammatory nature, IgG4 is involved in a variety of pathological conditions such as autoimmune disease and cancer. To investigate whether… #BioRxiv #MassSpecRSS

(BioRxiv All) sORF-Trans2MS: a two-module deep learning framework for sORF translation and MS-supported microprotein prediction: Ribosome profiling is widely used to identify translated small open reading frames (sORFs), but existing prediction models often generalize poorly… #BioRxiv #MassSpecRSS

(BioRxiv All) Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice: Traumatic brain injury (TBI) is a risk factor for Alzheimer's disease (AD), and both conditions are associated with impaired… #BioRxiv #MassSpecRSS

(BioRxiv All) KRAS-driven metabolic reprogramming of enhanced MFSD2A-mediated lysophosphatidylcholine scavenging promotes survival and progression of pancreatic ductal adenocarcinoma: Oncogenic KRAS drives lipid reprogramming in pancreatic ductal adenocarcinoma (PDAC) to… #BioRxiv #MassSpecRSS

(BioRxiv All) Bottom-up engineering of EV-mimetic vesicles reveals selective protein loading and modulates cellular uptake and biodistribution: Biological systems such as extracellular vesicles (EVs) are highly sophisticated and functionally diverse. Despite growing… #BioRxiv #MassSpecRSS

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(BioRxiv All) Soil microbiome functions in plant-aphid dynamics are resilient to community restructuring during compost application: Abstract Background: Soil microbiomes play critical roles in plant health and resilience, yet it is still poorly understood how disruptions in… #BioRxiv #MassSpecRSS

(BioRxiv All) Conserved mycobacteriophage protein uses structural mimicry to displace host initiation factors: Compact viral genomes encode sophisticated strategies to reprogram host gene expression, often by co-opting rather than replacing the host RNA polymerase. How… #BioRxiv #MassSpecRSS

(BioRxiv All) The protein phosphatase 2A catalytic subunit Pph22 partners with Tap42 and Rrd2 to control viability and virulence in Cryptococcus neoformans: Protein phosphatase 2A regulates eukaryotic signaling, but the function of its associated regulators remains poorly… #BioRxiv #MassSpecRSS

(BioRxiv All) Single-cell proteomics resolves major cell populations and protein-defined chondrocyte states in the adult human osteoarthritic joint: Objective Single-cell RNA sequencing has transformed our understanding of cellular heterogeneity within osteoarthritic (OA)… #BioRxiv #MassSpecRSS

(BioRxiv All) Beyond HCD: complementary fragmentation chemistries expand HLA class I immunopeptidome discovery: Mass spectrometry based immunopeptidomics is limited by peptide identification. HLA class I ligands are non-tryptic, frequently carry low charge states and often… #BioRxiv #MassSpecRSS

(BioRxiv All) Functional validation and characterization of Slc39a8 genotype effects on ethanol consumption and related phenotypes: Alcohol use disorders are heritable, and large-scale genome-wide association studies have recently identified novel genetic loci that are… #BioRxiv #MassSpecRSS

(BioRxiv All) Protocol for Single-Cell Patch-Proteomics: identify specific proteins associated with electrophysiological properties from individual neurons: Single-cell patch-proteomics is a novel and powerful technique combining electrophysiological and quantitative proteomic… #BioRxiv #MassSpecRSS