#Orthodontic tension does more than move #teeth — it drives glycolysis-driven H3K18 lactylation and CXCL1 signaling, promoting inflammation-resolving macrophages and alveolar bone formation.👇
@ijosjournal.bsky.social
www.nature.com/articles/s41...

How do #gum infections lead to #bone loss? #Bacteria activate PITX2, causing gum cells to produce #SAA1 and send inflammatory signals to nearby cells. Blocking #PITX2 reduced inflammation and bone loss in mice.🤓
@ijosjournal.bsky.social
www.nature.com/articles/s41...

#RUNX2 helps bone-removing cells work. In mouse and cell studies, it activated a newly identified RNA, LncRNA-ROD, which bound QKI and protected Csf1r #mRNA from breakdown. Mice lacking this RNA showed less #bone resorption around teeth and delayed eruption.👇
www.nature.com/articles/s41...

Can #dental stem cells help rebuild #bone around teeth? Researchers made these cells produce more #IGFBP5 protein, reducing signs of ageing in lab tests. A #gel carrying the modified cells improved bone repair in rats with #gum disease.👍
@ijosjournal.bsky.social
www.nature.com/articles/s41...

#Ultrasound may help #bone heal by easing a molecular brake. In cells and mice, low-intensity pulsed ultrasound lowered Id3, which normally suppresses #BMP4 bone-building signals. Blocking #Id3 with a peptide further strengthened these signals and improved skull-defect repair in mice.👍

In mice, removing both #Piezo1 and #Piezo2 slowed the maturation of dentin-forming odontoblasts and reduced Wnt/β-catenin signaling. Adding #Wnt10a restored odontoblast development in cultured tooth germs, connecting mechanical sensing with #tooth development.👇
www.nature.com/articles/s41...

#Teeth and #jaws are shaped by more than genes. This review shows how forces from growth, chewing and #orthodontic treatment can guide cells, helping shape teeth, roots and jaws as they develop and continue to adapt over time.🦷
@brjournal.bsky.social
www.nature.com/articles/s41...

What if reshaping #mitochondria could help #bone heal? In stem cells, lowering #PFKM created donut-shaped mitochondria, improved cellular energy management and boosted bone formation. In rats, #gene delivery that suppressed PFKM accelerated repair of skull and thigh-bone defects.🤓

Every bite, word and facial movement places force on the #mouth and #jaw. This review shows how oral tissues sense and remember those forces, and how the same signals could guide healing through smarter, increasingly adaptive #biomaterials.🤓
@ijosjournal.bsky.social
www.nature.com/articles/s41...

Inflammatory #DNA webs can damage #bone around #teeth. Nanodecoys engineered with Toll-like receptor 9 released #DNase I under near-infrared light to clear them. In a mouse model of #periodontitis, treatment reduced bone-resorbing activity, supported bone formation, and limited bone loss.😀