Thank you! Yes, given the similarities to cortex, we think it’s a network thing, but definitely could local contributions too!

Thank you Mary Beth!

In this case, we think it could be solving the local credit assignment problem!

Thanks Ariel!

At reward, climbing fibers carried strong instructive signals - and optogenetic climbing fiber activation reinforced the pushing behavior. Congratulations to lead author Benjamin Filio and the rest of the team! The Wagner Lab is recruiting postdocs and graduate trainees: [email protected]

Granule cells formed dense, temporally extended predictive signals that bridged the delay. Individual cells rescaled when reward timing changed and generalized between water and dopamine rewards. Inhibiting granule cell activity during the delay disrupted push-for-dopamine learning and execution.

Mice learned to push for self-stimulation rewards delivered after a delay while we imaged cerebellar granule cells and climbing fibers. The two populations carried strikingly different signals across the action-to-reward interval.