Strong correlations between mutation rates and selective constraint in the human genome? https://www.biorxiv.org/content/10.64898/2026.10.08.757506v1

Phylogenetic conservation scores have long been used to identify selection targets in the genome. With machine learning, they take a new form and will likely grow in popularity. @apragsdale.bsky.social and I investigate their relationship with mutation rates

www.biorxiv.org/content/10.6...

Now out in Genetics:
academic.oup.com/genetics/adv...

I’m looking to hire one or two postdocs - possible projects include pop gen theory, methods development, and human evolutionary inference. Please share, and email if you are interested.

More info: evoldir.net/brian/evoldi...