How do DNA sequence features tune the timing, level or duration of gene expression?

Join us for a 4 year PhD @mrc-lms.bsky.social with @perez-carrasco.bsky.social @jamesware.bsky.social to build models and help us better predict the impact of non-coding sequence variation #devbio #quantitativebio👇

📣 New PhD position in our lab with @vmetzis.bsky.social zis.bsky.social and @jamesware.bsky.social. Join us to uncover how regulatory elements control the timing and dynamics of gene expression.

Interested in gene regulation, development and quantitative biology? 👇

www.findaphd.com/phds/project...

New preprint from our group disentangling stochasticity, cell-to-cell heterogeneity and interaction history in cytotoxic immune cells. Finding structure in the noise allows us to identify differences in the mechanisms of action of different antibody treatments. doi.org/10.64898/202...

The new AC-DC paper is out! ⚡
One small gene circuit, more than 30 distinct dynamical behaviours. Showing how small regulatory networks can hide a surprising amount of dynamical complexity. www.cell.com/cell-systems...

Our latest: Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data

From Marine Fontaine and @joadelas.bsky.social with David Rand in @plosbiology.org

A thread 🧵
doi.org/10.1371/jour...