Galli, Recher et al. @unibas.ch describe two patients with hypogammaglobulinemia associated with #MyotonicDystrophy type 1 (DM1), a rare and underdiagnosed monogenic neuromuscular disorder and provide clues to aid clinical immunologists in making a correct diagnosis. rupress.org/jhi/article/...

#HowITreat from Joseph Oved: In primary immune regulatory diseases and inflammatory disorders, targeted immune modulation may control symptoms for some, but alloHCT remains the only cure for many patients. rupress.org/jhi/article/...

#Infections #autoantibodies

Sbruzzi, Vianna et al. show that neutralizing #autoantibodies against type I IFNs are more frequent in severe, critical, and fatal #COVID19 cases in southern Brazil, highlighting their role in disease severity and extending global evidence to a Latin American population. rupress.org/jhi/article/...

In this month's issue of Arthritis Care & Research, we present a collection of special articles celebrating 50 years of pediatric rheumatology and the advancements in care that have been achieved.

Read the October issue:
acrjournals.onlinelibrary.wiley.com/toc/21514658...

Dr. Daniel Kastner, former NHGRI Scientific Director, was a visionary physician-scientist whose discoveries transformed the understanding of innate immunity and established the modern field of autoinflammatory diseases. Gupta, Goldbach-Mansk & Aksentijevich pay tribute: rupress.org/jhi/article/...

We all know recurrent infections is a hallmark of many primary immunodeficiencies, but what really is "recurrent"? In the electronic health record, recurrence is far from obvious. Aaron figured out a way to tease recurrence from the data. The impact is finding immune deficiency patients sooner. #IEI

#Exome sequencing can stratify the genetic risk of #CeliacDisease among first-degree relatives of affected individuals. A study from Talha Asif, Xiao-Fei Kong et al. (UT Southwestern) finds that about 10% of first-degree relatives carry a particularly high genetic risk. rupress.org/jhi/article/...