A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis
@natchembio.nature.comNature Chemical Biology
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A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
@natchembio.nature.com@natchembio.nature.comPUS7 pseudouridylation of noncoding RNA 7SK orchestrates human somatic cell reprogramming into iPS cells
@natchembio.nature.comProteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
@natchembio.nature.comHigh-resolution NMR spectroscopy of proteins in intact mitochondria
@natchembio.nature.comQC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of DHODH, a key enzyme in de novo pyrimidine biosynthesis
@natchembio.nature.comCell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation
@natchembio.nature.comCryo-EM structures of RNA polymerase II (Pol II) with cisplatin-induced DNA interstrand crosslinks (ICLs) reveal how Pol II remodels cisplatin-ICLs, stalls transcription, and commits lesions to transcription-coupled repair
@natchembio.nature.comA nontoxic proximity labeling method generating H2O2 in situ from D-amino acids enables protein and RNA proximity labeling and mapping RNA structural changes in vitro and in vivo
@natchembio.nature.comSRSF1 modulates the dark nucleolar cap pH to restore nucleolar integrity and function
@natchembio.nature.comA new Review highlights the mechanisms of molecules that disrupt translation in an amino acid or mRNA sequence-dependent manner
@natchembio.nature.comOur October issue is live!
www.nature.com/nchembio/vol...
Inspired by the phases of the moon, the cover artwork uses light and darkness to depict pharmacological control of chimeric antigen receptor (CAR) T cells
@natchembio.nature.comAllenes and alkynes can be biosynthesized via oxidative C(sp2)-demethylation of a prenyl group by fungal cytochrome P450s, expanding the catalytic repertoire of P450 enzymes
@ddu-dundee.bsky.socialReposted by @natchembio.nature.comHappy New Paper Day! We're excited to share this @natchembio.nature.com on #SmallMoleculeInhibitors of NorA, an efflux pump that is an important mediator of #antibioticresistance in #MRSA. It pumps antibiotics out , lowering their concentration in the cell.
@natchembio.nature.comAvaS is a pyridoxal-phosphate-dependent RNA-modifying enzyme, producing the tRNA modification ava2C from k2C in bacteria and plants and linking RNA chemistry to translational regulation of metabolic stress responses
@natchembio.nature.comA sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes
@natchembio.nature.comPlasma membrane order maps functional diversity in immune cells
@natchembio.nature.comChemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response
@natchembio.nature.comMacrophages transfer functional proteins to their surface during live-cell uptake
@natchembio.nature.comDirected evolution of Lantern enables rapid RNA and protein proximity labeling
@natchembio.nature.comMechanism of the Mtb DprE1-DprE2 epimerase complex involved in cell wall synthesis and inhibition by anti-tubercular drugs