@alexkwan.bsky.social
Professor at Cornell BME. Studying the neurobiology of psychiatric #drugs including #ketamine and #psychedelics.
@alexkwan.bsky.socialFinally, we discuss the importance of determining the cell type-specific effects of serotonin and psychedelics, which likely hold the key to their actions in the brain 4/4
@alexkwan.bsky.socialSerotonin has been implicated in reward learning, visual processing, and cerebrovascular function. We discuss mechanisms that may be similar for serotonin and psychedelics. 3/4
@alexkwan.bsky.socialWe compare their receptor selectivity profiles and consider the distinct spatiotemporal patterns of action, between serotonin and psychedelics. 2/4
@alexkwan.bsky.socialSerotonin biology as a basis for explaining psychedelic drug action - I learned a lot writing this review with @neuroknox.bsky.social
We know a good deal about serotonin, which should teach us how psychedelics work. But what’s the same? What’s different? 🤔
@alexkwan.bsky.socialReally cool work: visual learning in juvenile mice produces a persistent increase in spine density, resetting the synaptic setpoint 🤯, by @dianebissen.bsky.social @turrigiano.bsky.social Different starting point from the drug-induced plasticity we study, but perhaps a hint of related mechanisms
@portugueslab.bsky.socialReposted by @alexkwan.bsky.socialThe Department of Neurobiology and Behavior at Cornell University is hiring! Come and do cutting edge research on the neural basis of natural behaviors at NBB (nbb.cornell.edu). No animal too small, no behavior too strange!
Apply here: academicjobsonline.org/ajo/jobs/32592
@alexkwan.bsky.socialI try to not take them as much now as the PI 😅 My impression is they are more ‘healthy’ (translate: less tasty) and have fewer items. This box was packed to the brim.
@alexkwan.bsky.socialTIL European ThorLabs boxes >> American ThorLabs boxes. The stuff one learns on sabbatical 😀
@alexkwan.bsky.socialA great day at Basel catching up with the neuropharmacologists🇨🇭 @drfriid.bsky.social @dinoluethi.bsky.social
@alexkwan.bsky.socialCongrats! 🎉
@alexkwan.bsky.socialTwo large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others.
Should be a treasure trove of data for those interested in perceptual effects of #psychedelics
@alexkwan.bsky.socialWe worked hard to revise our #psilocybin & #ketamine snRNA-seq study to make it a resource.
Interactive web portal: psilo-seq.kwanlab.org
Annotated to @alleninstitute.org’s 16 neuronal and non-neuronal cell types, with updated analyses in preprint: www.biorxiv.org/content/10.1...
Check it out!
@alexkwan.bsky.socialExcited to share an early look at psilo-seq, a web portal for exploring our lab’s single-nucleus RNA-seq data in mice following psychedelic treatment.
