Most neurodegenerative diseases begin with misfolded proteins. A new project funded by the ARPA-H BIOGAMI program seeks to prevent neurodegenerative diseases by learning the language of disordered proteins in human cells at scale. Learn more: https://ow.ly/fLju50ZW7EC

🧠 ICYMI: IGI's Martin Kampmann's team uncovered a novel pathway to clear toxic #tau buildup in the brain, which could lead to a new strategy to treat dementias like Alzheimer's disease. Read more in his Cell - a Cell Press journal paper from earlier this year: https://ow.ly/2HFA50ZU3hu

📣New paper alert! From Pam Ronald's lab, "Signaling by a tyrosine-sulfated peptide balances growth and osmotic stress response in rice." 🌾Read here: https://ow.ly/RHLK50ZU32z

UC Berkeley has once again been named the top public university in North America in the 2027 Times Higher Education World University Rankings.

This adds to the growing list of #1 rankings Berkeley has earned this year. https://bit.ly/4delZyI

🧬 Out recently in Nature, IGI Investigator Yun S. Song has shared a new language model that can detect overlooked gene variants that impact human health. Learn more about how the Song lab is using #AI to investigate the human genome: https://ow.ly/44os50ZLxsk

IGI Affiliate Ksenia Krasileva on evolutionary design and innate #immunology. Join us today at 2 PM Pacific, in Berkeley or on Zoom! More info here: https://endpoints.news/in-a-changed-world-for-cystic-fibrosis-a-familys-fight-reveals-a-new-gap-in-care/

The 2026 UC Regents Innovation Awards honor two of IGI's Investigators! Fyodor Urnov for his contributions to #CRISPR medicine & Sue Lynch for her work on how the infant gut #microbiome. Read more: https://www.universityofcalifornia.edu/news/23-uc-innovators-who-are-changing-world

Predicting how #RNA folds would be a valuable tool for scientists, but #AI has not been able to crack the problem. A team at the IGI made significant progress on two key hurdles: limited structural data, and the fact that RNA can take on multiple shapes. Read more:
https://ow.ly/Yjgo50ZJcU3

📣 We are looking for a PhD student in 2027!

Interested in studying rapid evolutionary dynamics of species in changing climates?

Apply to the MOI LAB by Nov 19!

Flyer below & tinyurl.com/flyerphdmoilab

@ucberkeleyofficial.bsky.social
@innovativegenomics.bsky.social
@hhmi-science.bsky.social

As a postdoc, Phillip Cleves became the first person to genetically modify #coral. Now, he's trying to figure out how to save reefs and the magnificent ecosystems they host. Learn more about IGI's newest investigator: https://innovativegenomics.org/news/saving-coral-reefs-phil-cleves/

I wrote about what came before CRISPR 4 billion years ago: a war among viruses. Gift link: nyti.ms/3TBq4q0

Before #CRISPR, there was VIPR — a tool viruses used to battle each other with a never-before-seen genetic coding system, uncovered by researchers in the Doudna Lab. Read more here: https://ow.ly/KblS50ZOxwQ

#AI #LanguageModel #RNA

The latest in our Inside Genomics short video series — IGI researchers Sue Lynch at UCSF The Benioff Center for Microbiome Medicine & Ben Rubin Rubin Lab UC Berkeley are creating a new way to prevent & treat childhood #asthma by editing the #microbiome. Watch here: https://ow.ly/abyU50ZGLAR

🧬 Out today in Nature, IGI Investigator Yun S. Song has shared a new language model that can detect overlooked gene variants that impact human health. Learn more about how the Song lab is using #AI to investigate the human genome: https://ow.ly/44os50ZLxsk

Out today in Nature Nanotechnology, a Q&A with IGI's Niren Murthy on his new way to engineer lipid nanparticles (LNPs) for safer genome editing. Read it here: https://innovativegenomics.org/news/safer-lipid-nanoparticles-gene-editing/

Predicting how #RNA folds would be a valuable tool for scientists, but #AI has not been able to crack the problem. A team at the IGI made significant progress on two key hurdles: limited structural data, and the fact that RNA can take on multiple shapes. Read more:
https://ow.ly/Yjgo50ZJcU3

📝 BRIEF COMMUNICATION 📝

Targeted Knockout of CYP79A1 Reduces Cyanogenic Potential in Grain Sorghum - Groover et al.

🔗 doi.org/10.1111/pbi....

#plantscience 🧪 @evangroover.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social @natureatcal.bsky.social @berkeleymcb.bsky.social

Thanks to Proceedings of the National Academy of Sciences for highlighting our work on reducing methane emissions frow cows! This work is led by IGI Investigators Ermias Kebreab and Matthias Hess The Hess Lab @ UC Davis. Read the article: https://www.pnas.org/doi/10.1073/pnas.2626533123

#Asthma is one of the most common childhood diseases. IGI researchers Sue Lynch at UCSF The Benioff Center for Microbiome Medicine & Ben Rubin Rubin Lab UC Berkeley are creating a new way to prevent & treat asthma by editing microbes. More in our new Inside Genomics video! https://ow.ly/abyU50ZGLAR