@sergiuppasca.bsky.social
Professor at Stanford & Director of Stanford Brain Organogenesis
Lab: https://pascalab.org
Center: https://med.stanford.edu/brainorganogenesis.html
TED: https://go.ted.com/6WJy
Instagram: https://www.instagram.com/sergiu.p.pasca/
@sergiuppasca.bsky.socialThank you for the thoughtful summary and perspective!
@deisseroth.bsky.socialReposted by @sergiuppasca.bsky.socialThank you to everyone sharing in this moment!
I’m so grateful to all my trainees & collaborators…
dlab.stanford.edu/group-members
(pic: Peter and I together in 2017)
Reading for all those asking:
for technical details: dlab.stanford.edu
for everyone: deisseroth.org/projections
@sergiuppasca.bsky.socialThe latest @nature.com editorial discusses oversight as human neural organoid and assembloid research advances, highlighting discussions at Asilomar. An important conversation as the field moves forward.
Read more: doi.org/10.1038/d415...
@sergiuppasca.bsky.socialThe 5th edition of the CSHL meeting on neural #organoids, #assembloids & human development is approaching!
Since the first meeting in 2017, this has become a special forum for the field.
This edition promises outstanding speakers, strong trainee engagement & the perfect setting to hear the latest
@sergiuppasca.bsky.social@sergiuppasca.bsky.socialHere’s a short summary of our recent #xenocortication article in @nature.com, including the rationale, approach, key findings, application to disease modeling & current limitations.
A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary.
Article below 👇
@sergiuppasca.bsky.socialArticle here: www.nature.com/articles/s41...
@sergiuppasca.bsky.socialSuperb work from Helen Bateup’s lab in @nature.com this week, led by the remarkable Tommy Li— a former PhD student at Stanford & lan alumnus.
Using regionalized cortical #organoids, they discover glia as major players in tuberous sclerosis.
@sergiuppasca.bsky.socialPrecisely!
@sergiuppasca.bsky.socialthank you!
@sergiuppasca.bsky.socialThank you!
@sergiuppasca.bsky.socialarticle here: www.nature.com/articles/s41...
@sergiuppasca.bsky.socialNearly seven years in the making. Congratulations to an extraordinary team and wonderful collaborators!
@sergiuppasca.bsky.socialWe call these #xenocortical mice (XCX).
@sergiuppasca.bsky.socialTo address some of these limitations and obtain functional readouts relevant to disease biology, we generated #apallial mice, in which ~98% of the cortex & hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.
@sergiuppasca.bsky.socialTransplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.
@sergiuppasca.bsky.socialHuman neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations.
@sergiuppasca.bsky.socialToday in Nature @nature.com, we report a new approach to studying human brain development and modeling disease in vivo.
Open article link below 👇
@sergiuppasca.bsky.socialThank you @carlzimmer.com and @carolynyjohnson.bsky.social for the thoughtful coverage of our work
@kevinkelley.bsky.socialReposted by @sergiuppasca.bsky.social9/ Thank you to all co-authors. Really enjoyed working closely with Konstantin, Tilo, Paul Harary. Very grateful to @sergiuppasca.bsky.social for his vision, support, and mentorship.
Here is the paper: www.nature.com/articles/s41...
