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Sainsbury Laboratory Cambridge University (SLCU)

@slcuplants.bsky.social

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Sainsbury Laboratory Cambridge University (SLCU) is a research institute of the University of Cambridge dedicated to plant developmental biology.

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@dariuskos.bsky.socialOct 10, 2026, 12:55 PMReposted by @slcuplants.bsky.social

Happy #UKFungusDay!
Find me until 4pm in the Botanic Garden‘s FungiFieldDay @cubotanicgarden.bsky.social talking about my research on the interaction between #Marchantia and a fungus that loves #liverworts @slcuplants.bsky.social

@slcuplants.bsky.socialOct 10, 2026, 8:58 AM

We're at #NewScientistLive - use a scanning electron microscope, see like a bee, dive into computational modelling and chat to our scientists.
#PlantScience #NSL2026

@slcuplants.bsky.socialOct 5, 2026, 1:09 PM

Congratulations to authors Torkel Loman, Christian Schwall, Teresa Saez, Yujia Liu & James Locke

@slcuplants.bsky.socialOct 5, 2026, 1:09 PM

Understanding how these circuits generate different behaviours provides valuable information for designing gene circuits with predictable and programmable functions & exploring whether synthetic mixed positive and negative feedback loops allow other properties of gene expression to be tuned.

@slcuplants.bsky.socialOct 5, 2026, 1:09 PM

Using stochastic mathematical modelling & single-cell microscopy, they identified 10 distinct classes of gene expression dynamics, including stochastic pulsing, stochastic anti-pulsing, oscillations, bistability, homogeneous activation, heterogeneous activation & several intermediate dynamic states

@slcuplants.bsky.socialOct 5, 2026, 1:09 PM

🧬 How can simple gene circuits create complex cell behaviours?

James Locke’s team shows how a common genetic circuit, combining positive & negative feedback loops, can be tuned to produce a wide range of gene-expression patterns

🔗 doi.org/10.1038/s414...
🔗 www.slcu.cam.ac.uk/news/how-sim...

Schematic of the general mixed positive/negative feedback loop model. Here, a single component (σ) both activates and deactivates its own production. The activation depends on the presence of an input, and the deactivation is subject to a time delay. 10 line graphs showing Simulations for 10 different parameter sets, demonstrating the 10 different behaviours the model can achieve. Initially, the system remains inactive; upon triggering the input (marked by the red dashed lines), distinct behaviours emerge: a No activation. b Stochastic pulsing. c Oscillation. d Stochastic anti-pulsing. e Homogeneous activation. f Heterogeneous activation (three different simulations displayed). g Stochastic switching. h Stable bistability. This panel depicts two simulations. The first (dark blue) is initiated at the initial (inactive) state at the same time as the simulations in the other panels. The second (purple) is initiated at the time of the input (dashed red line) in the active state. There is no intrinsic way for the system to switch between these two states (however, it could happen by e.g., the addition of exogenous σ). i Single response pulse. j Intermediate activation. Source code used to generate this figure can be found in the provided GitLab repository.
@haopengyu.bsky.socialSep 30, 2026, 3:45 PMReposted by @slcuplants.bsky.social

Five wonderful years at @johninnescentre.bsky.social Thank you @yiliangding.bsky.social , @CarolineDean and @KeLi for your support and guidance, and to the whole lab and all my friends across JIC/TSL. Thanks to Yiliang for organising such a lovely send-off. Now on to the next adventure 💪

@haopengyu.bsky.socialOct 1, 2026, 8:57 PMReposted by @slcuplants.bsky.social

Welcome to join my group! Fully funded DTP PhD at @slcuplants.bsky.social Sainsbury Laboratory Cambridge University. Use AI foundation models to decode the regulatory grammar of plant cell identity. Open to international students. Deadline 8 Dec 2026.
bbsrcdtp.lifesci.cam.ac.uk/project-refe...

@rituparnagoswami.bsky.socialSep 29, 2026, 11:25 AMReposted by @slcuplants.bsky.social

It was such a lovely conference. I had so many insightful conversations and encouraging discussions. Talks were super amazing. #plantbiology #SLS26

@slcuplants.bsky.socialSep 29, 2026, 10:02 AM

A huge thank you to everyone who attended #SLS26 & our concluding keynote speaker @apmahonen.bsky.social for a fascinating talk and exciting new insights into how stem cell fate decisions are regulated in the vascular cambium.
Read more about his team's work: www.helsinki.fi/en/researchg...

Group photo of attendees at #SLS26Ari Pekka Mähönen presenting at #SLS26
@starmorph-syg.bsky.socialSep 28, 2026, 7:08 AMReposted by @slcuplants.bsky.social

Two of STARMORPH PIs were at the @slcuplants.bsky.social for #SLS26! Morphogenesis at its best! @xanderjones.bsky.social @srobertgroup.bsky.social

@thecimr.bsky.socialSep 28, 2026, 8:18 AMReposted by @slcuplants.bsky.social

Are you, or do you know, a yr 12 student interested in medicine/research careers? Applications now open for ISAC, our work experience scheme for local young people. Places at CIMR, @mrc-mbu.bsky.social @ims-mrl.bsky.social & @slcuplants.bsky.social Apply via link: www.cimr.cam.ac.uk/inspiring-sc...

@apaterlini.bsky.socialSep 28, 2026, 2:45 PMReposted by @slcuplants.bsky.social

Very excited to have Nadia Radzman, from @slcuplants.bsky.social, open our Monday Seminar Programme for this academic year! We’ve learned so much about plant peptides and neglected legume crops in her talk! 🫛🫘 Check out her www.broadnmind.com project! @instmolplantsci.bsky.social

Nadia Radzman presenting behind the podium
@umeaplantsciencecentre.seSep 24, 2026, 6:53 AMReposted by @slcuplants.bsky.social

Nice to see Elsa Gascon sharing her work at #SLS26! 🌱🔬

At UPSC, Elsa works in a collaboration between @stephanevrg.bsky.social and @icelabumu.bsky.social, combining modelling and plant biology to better understand the mechanics of plant tissues.

@icelabumu.bsky.socialSep 24, 2026, 7:17 AMReposted by @slcuplants.bsky.social

IceLab and @umeaplantsciencecentre.se interdisciplinary postdoc @gasconelsa.bsky.social presented at the 2026 Sainsbury Laboratory Symposium. Elsa is a computational biologist whose research focuses on the interplay between tissue topology and mechanical stresses during plant morphogenesis. 👏

@srobertgroup.bsky.socialSep 24, 2026, 12:00 PMReposted by @slcuplants.bsky.social

And the end of an amazing meeting! One of the best I have ever attended! Thank you @robinsonsci.bsky.social and News bâtis for the organization! @slcuplants.bsky.social #SLS26

@somssich.bsky.socialSep 24, 2026, 1:21 PMReposted by @slcuplants.bsky.social

Leonie is also on here: @leoniekraska.bsky.social 👍

@vinayshukla.bsky.socialSep 24, 2026, 4:31 PMReposted by @slcuplants.bsky.social

Thank you for organising this fantastic meeting! The quality of the science and the discussions at #SLS26 was superb, and the organizers did an excellent job.

@mromeiromotta.bsky.socialSep 24, 2026, 2:33 PMReposted by @slcuplants.bsky.social

This was an amazing meeting, with incredible speakers and a great atmosphere. Thank you to the organisers @robinsonsci.bsky.social and Neha Bhatia for the inspiring symposium!

@slcuplants.bsky.socialSep 24, 2026, 11:04 AM

@keikoutorii.bsky.social shared her work investigating patterning & differentiation in stomata in her #SLS26 talk "The plant-specific ACTL domain determines bHLH transcription factor heterodimeric partner selectivity during stomatal development"

More at: plant-stomata.org

#PlantScience

Keiko Torii presenting at #SLS26Graphic from Keiko Torii's first slide showing impact of stomata on plant life on land - taking in CO2 and producing O2 and H2O
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