High EBV-reactive IgG levels in serum are linked to typical inflammatory cerebrospinal fluid features in multiple sclerosis
@jsabatino37.bsky.socialJoe Sabatino
@jsabatino37.bsky.social
MS Neurologist, T cell immunologist, UCSF Dept of Neurology, Weill Institute for Neurosciences. All posts are my own and not on behalf of UCSF
@jsabatino37.bsky.social@jsabatino37.bsky.socialCompletely agree with you!
@jsabatino37.bsky.socialComparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
@jsabatino37.bsky.socialImmunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis
@labwaggoner.bsky.socialReposted by @jsabatino37.bsky.socialInduced regulatory B cells stably expressing IL-10 reverse central nervous system autoimmunity by targeting myeloid cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...
@kischober.bsky.socialReposted by @jsabatino37.bsky.socialInterested in antigen-specific T cell analyses for clinical immunomonitoring?
Have a look at our review, just out in @natureportfolio.nature.com Protocols: www.nature.com/articles/s41...
Led by S. Lazzaro and S. Koch, Curevac.
Special feature: The Supplementary Tutorial (interactive decision aid)
@jsabatino37.bsky.socialImpaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives
@jsabatino37.bsky.socialapologies, not sure i see what you mean. are you referring to the in vitro stim data in fig 5?
@jsabatino37.bsky.socialNon-ICANS Neurotoxicity Following BCMA CAR-T Cell Therapy Is Characterized by Distinct Clinical and Molecular Phenotypes
Congrats to Gupta lab!
@jsabatino37.bsky.socialI may have missed it but I thought only about 3% of B cells were CD3+ in blood, which is roughly similar to the percent of CD20+ T cells
@jsabatino37.bsky.socialThe trogocytosis plot of T cell-B cell interactions thickens!
T–B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclerosis
www.pnas.org/doi/10.1073/...
@brandon-beaber.bsky.socialReposted by @jsabatino37.bsky.socialThe FDA is reviewing an application for the investigational multiple sclerosis drug fenebrutinib which would be the first available bruton's tyrosine kinase inhibitor. They should make a decision within 6 months. multiplesclerosisnewstoday.com/news-posts/2...
@kischober.bsky.socialReposted by @jsabatino37.bsky.socialNew preprint from our lab, now on bioRxiv! We are VERY excited about this one!
www.biorxiv.org/content/10.6...
How does Epstein–Barr virus (EBV) immunity become linked to multiple sclerosis (MS)?
(1/8)
@biorxiv-immuno.bsky.socialReposted by @jsabatino37.bsky.socialA pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity https://www.biorxiv.org/content/10.64898/2026.09.28.753741v1
@jsabatino37.bsky.socialAutoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature
Congrats to Debanjana Chakravarty, Michael Wilson, Sam Pleasure and colleagues!
@jsabatino37.bsky.socialThe influence of anti-CD20-directed B cell depletion across different agents on Epstein-Barr virus-specific humoral and cellular immunity in patients with multiple sclerosis
@jsabatino37.bsky.socialReminder! If you are interested applying to our MS and Neuroimmunology fellowship, please attend our
virtual Open House on Friday, October 2 at 10-11 am PT.
We offer clinical and clinician-scientist training tracks
Registration here: ucsf.zoom.us/webinar/regi...
@biorxiv-immuno.bsky.socialReposted by @jsabatino37.bsky.socialMHC restriction is structurally encoded by the T cell receptor germline https://www.biorxiv.org/content/10.64898/2026.09.24.754241v1
@drmapaley.bsky.socialReposted by @jsabatino37.bsky.socialYou can now view our abstract using this link and the summary images below: www.biorxiv.org/content/10.6...
@obigriffith.bsky.social @malachigriffith.bsky.social @thehumanborch.bsky.social
@schumacher-lab.bsky.socialReposted by @jsabatino37.bsky.socialHi, we would like to introduce PAIR-Scan, an HLA-agnostic library-on-library screening technology that can identify reactive TCR–antigen pairs with optimal killing activity among up to ~100,000 possible candidate pairs in a single-step.
🧵(1/7)
www.biorxiv.org/content/10.6...