P.S. I lied: it's not my first. π
During my PhD in Dresden, I built EvoWorms, an interactive installation simulating evolution: each worm has a 10-gene genome, and your movements feed or poison them. Natural selection does the rest. π§¬

@loicaroyer.bsky.social
Sr. Director of Imaging AI @biohub. Researcher at the meeting point of #AI, #Microscopy, and #Biology using #zebrafish as model β co-creator of @napari_imaging and #Omega. #devbio #zebrahub #deeplearning #lightsheet #Imaging #dataviz
P.S. I lied: it's not my first. π
During my PhD in Dresden, I built EvoWorms, an interactive installation simulating evolution: each worm has a 10-gene genome, and your movements feed or poison them. Natural selection does the rest. π§¬
One more thingβ¦ π In the next room, @ilan-theodoro.bsky.social ran a second demo: petascale microscopy of zebrafish from labs across Biohub, flown through live with a joystick. More on that one very soon. ππ¬
To Ilan da Silva Theodoro (@ilan-theodoro.bsky.social), Javier Carmona, Vera Janssen (@verajanssen.bsky.social) and Thibaut Goldsborough: thank you for presenting the demos with me and telling these stories to visitors all day. π
Huge thanks to the Biohub marketing, brand and events teams who made it real, among them Anna Ziskin, Erin Pierce, Stephanie Warner and designer Rebekah Atwell; and to Mary Pat Kasravi, Stephanie Gardea, Travis Bill and the 15|40 team who produced the demo hall.
Not a one-off: the whole installation, twenty stories and every camera flight, is one Python file π
A coding agent + Luxar + your data = your own interactive universe.
It's built with Luxar, our open-source viewer for big scientific data: microscopy, cell atlases, connectomes, galaxies, ocean currentsβ¦ and now, it turns out, art. π¨
pip install luxar
Code: github.com/royerlab/luxar
Preprint: doi.org/10.64898/20...
Couldn't make it to the Mint? The whole installation, all twenty stories, runs in your browser: π
The universe itself is the ESM Atlas, from the ESM team at @biohub.org: Sal Candido, Alex Rives and colleagues (Candido et al. 2026). An extraordinary map of protein space, and a joy to bring to life. Thank you! π
Paper: doi.org/10.64898/20...
Twenty stories in all: photosynthesis, RuBisCO, ATP synthase, the phage universe, CRISPR, ice-binding proteins, the three ways animals invented smell, and TnpB, the jumping-gene nuclease that the Cas12 gene editors grew out of. β¨
Visitors touch a story on the kiosk and the camera flies across the universe to it: the family lights up, a soap bubble wraps around it, its structure spins, and the facts appear. π«§
Most of those sequences come not from organisms grown in a lab, but straight out of soil, seawater and guts. One cluster in four has no characterised member at all. That's the dark proteome, glowing behind me. π
What you're looking at: each point is a family of proteins that ESM, a protein language model, reads as alike. Together they stand for 817 million proteins. π§¬
My first digital media art installation. π¨
The ESM Protein Universe: 7.7 million protein families from 6.8 billion sequences, on a 16Γ16 ft wall at @biohub.org's AI Γ Bio Summit, at the Old Mint in San Francisco. π§΅π
And the day itself: Biohub's AI Γ Bio Summit at the Old Mint in San Francisco put biologists, AI researchers, engineers and funders in one room. Congratulations to the Biohub team for the leadership in bringing this community together, for the benefit of all of us. π
Joining them: Google DeepMind, Isomorphic Labs, Meta, NVIDIA, @alleninstitute.org, @broadinstitute.org, @gladstoneinst.bsky.social, @humancellatlas.org, @proteinatlas.bsky.social, @sangerinstitute.bsky.social and more.
The biggest coordinated push yet for open, AI-ready biological data.
What a day! π
@biohub.org, @departmentofenergy.bsky.social and NIH just announced $1.8 billion for the Virtual Biology Initiative: open, AI-ready data for models that predict how cells respond to disease and treatment. π§¬π€
And thank you to Walter Reade, MarΓa Cruz and the whole @kaggle.com team for running it with us, and to every participant who spent these past months staring at zebrafish nuclei. ππ
Huge thanks to the @biohub.org team who built this challenge: Thibaut Goldsborough, @jookuma.bsky.social, @xiang-zhao.bsky.social, Gordon Leary, @teunhuijben.bsky.social, @ilan-theodoro.bsky.social, @kyleharrington.com and Chi-Li Chiu. π
What's next: an in-person Cell Tracking Workshop at Biohub in Redwood City, Nov 30 to Dec 3, bringing the tracking and bioimaging community together, with our prize winners invited. Time to compare notes and chart where the field goes next! π§¬
It all stays open: CC0 data, winning code under MIT, writeups already up.
1st-place writeup: kaggle.com/competition...
Metric code: github.com/royerlab/ka...
#OpenScience