@proteinatlas.bsky.social
The Human Protein Atlas (HPA) aims to map all human proteins in cells, tissues, and organs using integration of various omics technologies. The publicly available database contains millions of high-resolution images.
@proteinatlas.bsky.socialPodocytes are specialized epithelial cells of the glomerulus, the main filtration unit of the kidney. Microtubules in the podocyte are vital to its function and here the microtubule associated protein MAP6 is highlighted in glomeruli using mIHC/IF.
@proteinatlas.bsky.socialBreast cancer is the most common cancer among women worldwide with more than 2 million new cases diagnosed each year. The cancer develops in the mammary gland with invasive ductal carcinoma (IDC) being the most common type accounting for 80% of the cases.
@proteinatlas.bsky.socialChanges in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene FH.
@proteinatlas.bsky.socialThe protein FATE1 is abnormally expressed in many cancer types and using mIHC/IF it is shown to localize (green) to the cytoplasm (red) and nucleus (magenta) of Sertoli cells that support the developing sperm cells within the seminiferous ducts of testis.
@proteinatlas.bsky.socialThe expression of PDX1, the transcription factor regulating the embryonic development of the pancreas and expression of insulin in beta cells in the islets of Langerhans, is shown to localize (green) to the nucleus of beta cells (magenta) using mIHC/IF.
@proteinatlas.bsky.socialCurrent therapies inadequately target T-cell pathways in autoimmune and inflammatory diseases limiting durable disease control. In a recent publication a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses is identified.
@proteinatlas.bsky.socialA Protein Science article presents the HPA Multiplex tissue resource, with 1,106 proteins analyzed across eight antibody panels. Mapping proteins to cell types, cell states, and tissue structures give deeper insights in protein expression in human tissues.
