Lara K. Mahal

@glycocode.bsky.social

CERC in Glycomics, Director of Glycomics Institute of Alberta(www.glyco-alberta.ca), Professor of Chemistry, Univ. of Alberta. Work on #glycotime with lectin microarrays and discovering new aspects of #miRNA. Opinions are mine (she/her). www.glycocode.org

@glycoshape.orgReposted by @glycocode.bsky.social

Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️

doi.org/10.64898/202...

Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪

screenshot of Fig. 2 in the paper, titled "Systematically altering steric restriction controls glycan processing" the following corresponds to the figure caption in the paper. Panel a, AF3-predicted protein with GlycoShape-modeled Man9 glycan (green) for glycoproteins THRgly1-4. b-d, Deconvoluted intact mass spectra for analyzing native glycosylation with 1–3 major peaks corresponding to glycosylation shifts labeled. Glycans matching in theoretical molecular weight to the corresponding shift are schematically annotated as follows: mannose residues as green circles, N-acetyl glucosamine residues as blue squares, galactose as yellow circles, sialic acid as pink diamonds, and glucose as blue circles. Unglycosylated sizes are estimated based on predicted MW and labeled, when present. b: Native glycosylation. c: Native protein digested with Endo H. d: Overlaid protein from kifunensine-treated cells (color, solid line) and digested with Endo H (gray, dotted line). Estimated predominant glycans present are shown in MW (Da) differences from predicted unglycosylated size. For peak table see Supplementary Data S3; amino acid sequences provided in Supplementary Data S1.
@jenlove.bsky.socialReposted by @glycocode.bsky.social

This is amazing work, and he, along with Henri Kagan and Donna Blackmond deserve this Nobel Prize. Oh, wait... I think you missed someone on that list.

@seananmcguire.bsky.socialReposted by @glycocode.bsky.social

So we don't get to be "the fun ones," and we don't get asked back, because when our official duties ended, we didn't go to the bar to join the after-hours social party. It's not required, not mandatory, but the social impact is very real.

@seananmcguire.bsky.socialReposted by @glycocode.bsky.social

I have been a guest at conventions where, during the pre-con walk through, my handler has pointed out the bar and mentioned how some guests are "more fun" and "get asked back," then names only men. Because a lot of female guests aren't comfortable hanging out around alcohol with strangers.

@plaguepoems.bsky.socialReposted by @glycocode.bsky.social

The climatologist 
told me 
the problem 
is we don’t see 
people far away 
as real people. 
The programmer 
told me 
the problem 
is we don’t see 
people online 
as real people. The ethicist 
told me 
the problem 
is we don’t see 
other people 
as real people.

@mehr.nzReposted by @glycocode.bsky.social

early-career academics, if you don't have a website, make yourself one. yes it's annoying but just do it it can be plain text on a white background, or google sites, or even a free Wix one with ads. nobody cares we just need to be able to look you up, quickly, bc there's like 100 other apps here

@trantteam.bsky.socialReposted by @glycocode.bsky.social

#Chemsky

Am actively recruiting graduate students for 2027. Looking for a total of 4-6 students to join the team. Synthetic organic chemistry, molecular biology/cell biology, and biophysics are priorities, but we will consider almost anything in the molecular sciences if it aligns with our work!

@jeymccreight.bsky.socialReposted by @glycocode.bsky.social

Reposting because all of my jobs have always come from someone in my network referring me or knowing someone who needs a science communicator 🤞

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