Instituto de Neurociencias CSIC-UMH

@neuroalc.bsky.social

El IN es el mayor centro financiado con fondos públicos dedicado a la investigación del cerebro tanto en condiciones normales como patológicas en España.
Centro de Excelencia Severo Ochoa desde 2014.
https://in.umh-csic.es/es/

@sciencex.bsky.socialReposted by @neuroalc.bsky.social

In mice, lower inhibition in a hippocampal region improved detection of tiny object shifts; higher inhibition favored stable memory representations. What naturally controls the balance remains unknown. doi.org/hck5p7

@canalslab.bsky.socialReposted by @neuroalc.bsky.social

Congratulations to all the team! Equilibrium between flexibility and stability of memories under the control of PV cells in the dentate gyrus!

@neuroalc.bsky.social

Model predictions were tested in mice learning associations between objects, locations, & environments. Results confirmed a dynamic balance between updating memories & maintaining consistency.
🎥 Santiago Canals & Encarni Marcos explain the findings👇🧵4/5
youtu.be/TU_kGtrncvI

@neuroalc.bsky.social

💻 Why isn’t lower inhibition always better? A computational model showed there is no single optimal level: lower inhibition can favour discrimination when memory load is low, while higher inhibition helps maintain consistent representations as information increases. 🧵3/5

@neuroalc.bsky.social

🔬 The team manipulated inhibitory activity in the dentate gyrus of mice during memory encoding. Lower inhibition increased sensitivity to small changes between similar experiences, while higher inhibition made memory representations more resistant to change. 🧵2/5

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