Happy to share this link to @yuritakahashi.bsky.social ‘s paper that is now out in @embojournal.org . Is you make cells migrate, they become migratory cell states!
@bensteventon.bsky.socialReposted by @embojournal.org
The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org Fast-fair-transparent / Open Access / Open Science
@bensteventon.bsky.socialReposted by @embojournal.org@embojournal.orgWhy does endogenous, but not exogenous leptin remain effective in restraining feeding in obesity?
@tunepers.bsky.social, Martin G Myers and collaborators identify a set of CNS neurons controlling AgRP neuron sensitivity to orexigenic stimuli
link.springer.com/article/10.1...
@embojournal.orgHow about stress-induced ribosome hibernation in archaea?
@diorgeps.bsky.social, @archaeon-alex.bsky.social, Joey Davis et al identify conserved archaeal factor AHA with evolutionary link to bacterial hibernation-promoting factor HPF & eukaryotic energy sensor AMPKγ
link.springer.com/article/10.1...
@embojournal.orgNew review!
Myrthe Klaver et al @demarialab.bsky.social reflect on the field of cellular #senescence and its continuing evolution, from initial discoveries to technology-driven conceptual transitions and the emerging era of targeted interventions
#WeekendRead
link.springer.com/article/10.1...
@embojournal.orgPhage therapy approaches depend on phage suppression of host bacterial physiology - and P. aeruginosa phage PaoP5 has a protein, Ped1, that does this in a dual manner: via DNA degradation and replication inhibition
Haihua Liang, Tietao Wang and collaborators
link.springer.com/article/10.1...
@juliansalelab.bsky.socialReposted by @embojournal.orgCongratulations Tanmay, on receiving the @embo.org Gold Medal! @mrclmb.ac.uk @embl.org @dunnschool.bsky.social
@embojournal.orgIssue 19!
Highlight: The plasticity of Paneth cells
Review: co-activator stepbrothers SAGA & ATAC
Perforin-2 cytosolic antigen escape mechanism
TAD hierarchies & cohesion zones
Hox/Meis transcription & neural crest diversification
Cover by Trowitzsch, Tampé et al
link.springer.com/journal/4431...
@embojournal.orgWhy is #replication initiation factor Mcm10 essential for replicative helicase activation in yeast but not animals?
@labiblab.bsky.social, @yyxia.bsky.social et al now find similar roles for worm & human homologs, masked by partial redundancy with SLD-2/RECQL4
link.springer.com/article/10.1...
@embojournal.orgAnother #RefereedPreprint ℅ @reviewcommons.org :
Fumiyo Ikeda 池田 史代 and coworkers show that LUBAC subunit HOIL-1 restrains linear ubiquitination to maintain dynamic properties of p62 condensates and promote aggregate clearance
link.springer.com/article/10.1...
@embojournal.orgBacteria have evolved #ubiquitin regulatory enzymes are distinct in sequence & structure from their eukaryotic counterparts - a new screening workflow established by @jnpruneda.bsky.social and collaborators allows their identification from complex bacterial samples
link.springer.com/article/10.1...
@embojournal.orgNew insight into host-parasite interactions involved in Toxoplasma invasion:
Sebastian Lourido and coworkers find the parasite microneme MIC1/4/6 complex to cluster host N-glycans into membrane microdomains to promote rhoptry discharge
link.springer.com/article/10.1...
@embojournal.orgDoes it matter which route a cell takes towards whole-genome duplication?
Simon Gemble, Renata Basto et al show that only mitotic slippage leads to softening of the nucleus, making it more susceptible to deformation through the microtubule cytoskeleton
link.springer.com/article/10.1...
@embojournal.orgHow doe BRCA1 suppress Group 1 genomic tandem duplications?
@ralphscully.bsky.social show that Brca1 coiled-coil mutant mouse models remain competent for suppression of tandem duplications despite being defective for homologous recombination
link.springer.com/article/10.1...
@embojournal.orgWhat defines limits & regulation of epigenetic inheritance?
Florian Steiner et al show altered genomic distribution of histone modification H3K27me3 can be transmitted across C. elegans generations through successive SET-32 & MES-4 action that alters its deposition
link.springer.com/article/10.1...
@embojournal.orgEMBO Workshop on Bacterial Networks: Our microbiology editor Ieva Gailite presenting the @embojournal.org poster prize to Morgane Wuckelt from the @mathieucoureuil.bsky.social lab - congratulations!
@embojournal.orgWanqi Liang and collaborators show that rice ZEP1, a transverse-filament protein of the synaptonemal complex, coordinates anti-crossover activities and crossover pathways to promote proper intermediate processing and faithful recombination during #meiosis
link.springer.com/article/10.1...
@embojournal.orgIssue 18:
Comment on timescale mismatch in anthropocene evolution
Review: tRNA evolution in photosynthetic organisms
Method: Engineering editopes to make tumor neoantigens
Ribosome-associated protein quality control during CFTR synthesis
Cover: Alessio Zippo et al
link.springer.com/journal/4431...
@embojournal.orgAkiyasu Iwase, Hiroki Kurihara et al show that loss of Hox-dependent regional identity enables pharyngeal neural crest cells to acquire new fates during mammalian heart development
link.springer.com/article/10.1...
@mitoworld.bsky.socialReposted by @embojournal.orgHow do cells decide whether to store energy as fat or mobilize it? #Mitochondria play a pivotal role! Learn more from Dr. Shirihai on his @embojournal.org paper on the Mitoblog:
#UMDF #mitoscientists #Brownadiposetissue #adiposetissue #mitochondrialmetabolism
@embojournal.orgBiochemical diversity of tubulin:
Carsten Janke, Zdenek Lansky and collaborators screen 46 microtubule-associated proteins to reveal their distinct affinities to tubulin isotypes and posttranslational modifications
link.springer.com/article/10.1...