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A journal dedicated to publishing the latest advances across all areas of cell biology. Part of @natureportfolio.nature.com
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@squeezycellslab.bsky.socialReposted by @natcellbio.nature.comHave you ever wondered how cells in developing embryos manage to squeeze through tiny spaces? And how do they cope with mechanical stresses imposed by surrounding tissues?
Check out our paper, now out @natcellbio.nature.com :
www.nature.com/articles/s41...
@natcellbio.nature.comð°Read also the News & Views article written by Jing Xie & Daniele Fachinetti:
ðhttps://rdcu.be/Apw9ET8Y3gxa
@natcellbio.nature.comâ @lgudlin.bsky.social, @krunovuk.bsky.social, Novak et al propose spindle scaling in response to chromosome crowding consistent across eukaryotes; metaphase plate width scales with genome size following a power law with an exponent of ~1/3. @ivatolic.bsky.social
www.nature.com/articles/s41...
@natcellbio.nature.comâWernaart, Fumagalli et al. report ADAR1 and FTSJ1 as regulators of tryptophan-to-phenylalanine substitution in cancer. ADAR1 sustains mistranslation via ribosome quality control. FTSJ1 methylates tRNATrp and allows tRNATrp mischarging by phenylalanine.
www.nature.com/articles/s41...
@natcellbio.nature.comâ @nadlerlab.bsky.social @mathilda95.bsky.social & co evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma membrane.
www.nature.com/articles/s41...
@natcellbio.nature.comâVinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5â13 human #meninges and perform comparative studies with #meningioma data.
www.nature.com/articles/s41...
@natcellbio.nature.comâ @teichlab.bsky.social , To, Pett, Dufva & co perform single-nucleus RNA and ATAC sequencing, as well as spatial transcriptomics, to study human meninges at 6â21âweeks post conception.
www.nature.com/articles/s41...
@natcellbio.nature.comâMeiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.
www.nature.com/articles/s41...
@natcellbio.nature.comâLi, Jiang et al present DePass, a graph-based #DeepLearning framework for integrating paired #multiomics data in spatial and single-cell contexts. A dual-enhancement approach is used to remove noise from raw omics data.
ðhttps://rdcu.be/kxnPQVtLvtba
@springernature.comReposted by @natcellbio.nature.comEvery published paper has a story, conversations, & people behind it. Meet Sabrya, Senior Editor, as she shares insights into her work and what makes her experience at Springer Nature meaningful.
Explore careers: group.springernature.com/gp/group/car...
@natcellbio.nature.comâChanges in Genentechâs scientific organization, as artificial intelligence (AI) is being made increasingly central to its research strategy, highlight a broader question: how will the use of AI reshape the scientific discovery process?
ðhttps://rdcu.be/LPKhMQp2Vs8a
@natcellbio.nature.comð°Read also the News & Views article written by Zhengyue Cao & Cunqi Ye on both studies:
ðhttps://rdcu.be/TeRExRneF4ka
@natcellbio.nature.com@natcellbio.nature.comâTwo studies show that the ER-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converted into BMP. These results provide insight into CLN8 Batten disease.
www.nature.com/articles/s41...
@natcellbio.nature.comâ @majarad.bsky.social et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit the ATPase DFCP1, which promotes lysosome repair.
www.nature.com/articles/s41...
@natcellbio.nature.comâXie, Tan, Mo et al. show that a liver-specific bipartite structure of the active X chromosome is lost early in hepatocarcinogenesis in mice & humans, driving X-linked gene activation and premalignant transformation, particularly in males.
ðhttps://rdcu.be/mqgkumVG1YFa
www.nature.com/articles/s41...
@natcellbio.nature.comâXu, Guo et al. report suppressor screens in C. elegans to counteract tubulin mutants. They report several missense variants in tubulin genes that may restore microtubule architecture and dynamics.
ðhttps://rdcu.be/PFSRCSoPDyoa
www.nature.com/articles/s41...
@natcellbio.nature.comâ @gabrijelad.bsky.social & co report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the nuclear speckle periphery and undergo synchronous splicing at mitosis, thus contributing to their temporal regulation.
bit.ly/4xpanzZ
@natcellbio.nature.comðOur September issue's out!
Cover: #embryo implantation mechanics
ðPerspective on #ferroptosis
ð¬: #mechanobiology #CellDeath #autophagy #chromatin #RNA #mitosis #circadian control #ribosome #brain #ExtracellularVesicles #transcription #MassSpectrometry & more!
@natcellbio.nature.comâ @anhhle2702.bsky.social @mayorlab.bsky.social & co show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions.
www.nature.com/articles/s41...
