TRAstonDrs (@castltrastondrs.medsky.network)

@mikehoney.bsky.social Oct 11, 2026, 2:03 PMReposted by @castltrastondrs.medsky.network

@trishgreenhalgh.bsky.social Oct 1, 2026, 10:18 PMReposted by @castltrastondrs.medsky.network

My new paper, just out:

Interrogating Evidential Pluralism: A Critical Comparison of Approaches to Incorporating Mechanisms in Evidence Synthesis

#philippic

philmed.pitt.edu/philmed/arti...

@castltrastondrs.medsky.network Oct 11, 2026, 1:45 PM

While there is life there is happiness. There is much, much before us. Leo Tolstoy Talking to myself on Sunday morning

The Northern Lights reflected in the dawn light through the window.

Scottish Highland Autumn evokes a nostalgic feeling of once being truly home.

@castltrastondrs.medsky.network Oct 11, 2026, 10:36 AM

Unfortunately, I don’t but reading is the way of learning…

@castltrastondrs.medsky.network Oct 11, 2026, 5:46 AM

A single photo can sometimes clear your mind and offer a glimmer of hope.

@tnicholsmd.com Oct 11, 2026, 4:42 AMReposted by @castltrastondrs.medsky.network

I have been saying this forever, but people don’t quit jobs, they quit leadership. Great leaders can make impossible jobs seem possible and worth doing. Terrible leaders can make the absolutely perfect job intolerable.

@castltrastondrs.medsky.network Oct 11, 2026, 5:33 AM

#WorldMentalHealthDay🤗 Just remember to “be kind” today. Everyone needs a helping hand, including you❣️ Talk to yourself like you would to someone you love. Brené Brown

@castltrastondrs.medsky.network Oct 11, 2026, 5:15 AM

Do not confuse truth with the opinion of the majority Jean Cocteau

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

#Influenzavirus, #SARSCoV2, Human Immunodeficiency Virus (HIV), and Zika virus

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

🦠 Common Viral Triggers
* #Herpesviruses: Includes Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Varicella-zoster virus (VZV), and Herpes simplex virus type 1 (HSV-1)
* #HepatotropicViruses: Includes Hepatitis A, B, C, and E (HEV).
* Respiratory & Other Viruses: Includes

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

leading to complement activation, T-cell-mediated inflammation, demyelination, or axonal degeneration

onlinelibrary.wiley.com/doi/10.1002/...

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

* #MolecularMimicry: Viral (or bacterial) epitopes share structural similarities with peripheral nerve components (such as gangliosides), causing the host immune system to generate cross-reactive autoantibodies
🦠Viral infections can dysregulate the immune response,

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

#GuillainBarrésyndrome (GBS) can be triggered by several viral and bacterial pathogens that induce peripheral nerve damage through immune-mediated mechanisms such as molecular mimicry

link.springer.com/article/10.1...

link.springer.com/chapter/10.1...

www.researchgate.net/publication/...

Representation of molecular mimicry, pathophysiological mechanism of GBS. The pathophysiology of GBS is evidenced by the mechanism of molecular mimicry, in which the virus shares epitopes common to neuron components, such as the myelin sheath and axonal lining. Thus, direct virus infection triggers the activation of the immune system and APC precursor cells, which differentiate into T and B lymphocytes. Also, the viral epitope is recognized by the B lymphocyte and the T lymphocyte releases isoleucine such as IL-6 and interleukin 4 (IL-4), in addition to cytokines such as TNF-α and interferon-gamma (IFN-γ) for macrophage activation, triggering local inflammation that can be exacerbated. Thus, there is the production of antibodies (ANTI-GM1) to attack the virus, however, by sharing epitopes, these antibodies also attack components of the neuron. The recruitment of more macrophages increases inflammation, as well as the performance of the microglia that release cytokines such as IFN-γ and interleukin 1 beta (IL-1β). Finally, the neuron is in hyperinflammation and operates with its reduced functionality or loses it definitively, being able to suffer cell death and causing irreversible damage to the patient with this syndrome

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

Guillain-Barré syndrome (GBS) and variants such as Miller-Fisher syndrome (MFS) have been reported following #COVID infection..

@castltrastondrs.medsky.network Oct 11, 2026, 5:13 AM

#Medsky🧪 #IDsky #vaccinesmatter #publichealth.😷💉Are you up to date on your vaccinations? #Covid can dramatically change your life & potentially lead to early retirement & loss income. #LongCovid can rob your memory & co-infection is the worst.
hrcak.srce.hr/351770
link.springer.com/article/10.1...

@jci.org Oct 10, 2026, 9:01 PMReposted by @castltrastondrs.medsky.network

Weekend Spotlight💫: As part of JCI’s review series on emerging therapeutic strategies in breast cancer, Fanucci et al. present: Toward targeted therapeutics for lobular breast cancer: doi.org/10.1172/JCI2...
stoverlab.bsky.social

@castltrastondrs.medsky.network Oct 10, 2026, 6:15 PM

Distance brings sweetness. Absence tames what is near. Christian Bobin

@castltrastondrs.medsky.network Oct 10, 2026, 6:04 PM

The two shortest and oldest words, yes and no, are those that require the most reflection. Pythagoras 📌

@castltrastondrs.medsky.network Oct 10, 2026, 5:49 PM

before a scheduled vaccination, successfully mitigating uncomfortable side effects and improving global vaccine uptake
@eurekalert.bsky.social
www.eurekalert.org/news-release...

pubmed.ncbi.nlm.nih.gov/42848888/

@castltrastondrs.medsky.network Oct 10, 2026, 5:49 PM

Fever and systemic side effects are leading drivers of vaccine hesitancy. These findings open up an exciting new avenue for "precision vaccinology". In the future, clinicians might utilize short-term targeted dietary interventions or microbiome-modifying strategies to reshape gut health