@erictopol.bsky.social
physician-scientist, author, editor
https://www.scripps.edu/faculty/topol/
Ground Truths https://erictopol.substack.com
SUPER AGERS https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
@erictopol.bsky.socialHealthy aging: the immune system's prominent links from 12 million single-cell RNA sequencing and proteomics in 8 cohorts
www.cell.com/immunity/ful...
@erictopol.bsky.socialWhy do small dogs live longer than large dog species, and what is the biologic basis of differences in lifespan and healthspan?
Epigenetics.
There's a lot in the methylation pattern of dogs to explain this
@science.org
science.org/doi/10.1126/...
@erictopol.bsky.socialNew @science.org
A breakthrough in understanding why do we get fever and an inflammation response to vaccines.
The gut microbiome chronic production of flagellin
Paves the way to potentially prevent these acute phase side-effects in the future
www.science.org/doi/10.1126/...
@erictopol.bsky.socialWho do you think was responsible, for Francis's firing, Jeremy?
@jeremymberg.bsky.socialReposted by @erictopol.bsky.social@erictopol.bsky.social Podcast with Michael Lewis about Blockers including an extensive discussion of the Francis Collins chapter.
@erictopol.bsky.socialSemaglutide (Ozempic) consistently reduced proteomic organ age 2-4 years for the heart, artery, and kidney clocks across 5 placebo-controlled trials
researchsquare.com/article/rs-1...
@erictopol.bsky.socialHe spoke to the DOGE team members to get the plan of attacks
@erictopol.bsky.socialPublished today, there's a lot in Michael Lewis's new book we didn't know about. Including the NIH, unbridled assertion of power, cruelty, and many civil servant heroes (the "blockers")
erictopol.substack.com/p/michael-le...
@erictopol.bsky.socialA "normal" mammogram interpreted by AI can accurately forecast high-risk of breast cancer in the next 5 years. Approved by FDA, now becoming available. But it should be free and part of every mammogram readout.
Front page @nytimes.com today,
www.nytimes.com/2026/10/01/w...
@erictopol.bsky.socialCan we prevent the process and these diseases?
erictopol.substack.com/p/loss-of-ce...
@erictopol.bsky.socialThe list of reported benefits of the GLP-1 drug family that are weight-loss independent continues to grow. My tally with citations
@erictopol.bsky.social
@erictopol.bsky.socialIn the new @science.org special issue on women's health, a 5★ review of menopause hormone therapy to promote healthy aging
science.org/doi/10.1126/...
@erictopol.bsky.socialWhy do our cells age?
It's not just wear and tear, accumulated damage.
Loss of cell identity takes center stage.
A new Nature paper and connection with prior work that substantially advances the science of aging. In the new Ground Truths.
@erictopol.bsky.socialExercise slowed epigenetic aging again. This time in a randomized controlled trial among breast cancer survivors.
academic.oup.com/jnci/advance...
@erictopol.bsky.socialMeasles: What is likely going to happen in Florida (and much of the US) as MMR vaccination has dropped below the threshold needed to prevent outbreaks?
Hundreds of deaths in the next 5 years projected throughout the US.
www.pnas.org/doi/full/10....
@erictopol.bsky.socialThe word of the day: Zombified
www.nytimes.com/2026/09/26/h...
@erictopol.bsky.socialA partial list of factors that affect HRV
@erictopol.bsky.socialHow forever chemicals (PFAS) block our immune response to viruses
www.pnas.org/doi/full/10....
@erictopol.bsky.socialMore on this, horrifying
