The Lancet

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Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.

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🧠 Migraine is a chronic neurological disorder that affects over 1 billion people globally each year, with women predominantly affected.

A new Seminar discusses typical symptoms, mechanisms, and treatment options: spkl.io/633257VNQH

Cross section of a human brain illustrating the pathophysiology of migraine with aura. Copyright: Elsevier Ltd. All rights are reserved.
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The 17 catastrophic threats–from climate change to antimicrobial resistance to malicious use of AI–are interconnected. The Commission doesn’t offer a fixed policy ranking but provides decision-makers with a common framework for coordinated action.

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Use of an AI chatbot ahead of GP appointments required no safety interventions in first real-world small study. However, authors caution that this study doesn't suggest AI chatbots are able to diagnose or triage patients without a doctor's oversight.

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Figure showing the study design. For each patient, the study flow consisted of three distinct steps: (step 1) the patient conversed with AMIE through a synchronous text chat interface while an AI supervisor observed the patient–AMIE chat on a video call with screen sharing to ensure patient safety; (step 2) the patient saw a PCP in person or via telehealth after the AMIE chat, with the PCP having access to the AMIE chat transcript and summary; (step 3) 8 weeks after the provider visit, the adjudicated reference diagnosis was extracted from the patient's chart and three independent clinical evaluators rated the chat conversation quality as well as the management plan from both AMIE and PCP in a masked and randomised manner. Copyright: 2026 Elsevier Ltd. All rights are reserved.
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Peripheral arterial disease (PAD) affects more than 300 million people worldwide—yet it remains under-recognised, underdiagnosed, and undertreated.

A new Editorial discusses a Lancet Series aiming to address this major health burden: spkl.io/633207pL2I

Promotional card for The Lancet's October 3, 2026 Editorial. Image is of a Doppler ultrasound for ankle-brachial pressure index. Text reads 'Editorial: Peripheral arterial disease: counting what matters'.
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In our latest issue, a study evaluates whether wealth redistribution policies can mitigate the health impact of the current official development assistance (ODA) defunding crisis.

Read the study & explore the full issue: spkl.io/633257p2T3

Cover of The Lancet's October 3, 2026 issue. Quote reads: We further project that, if current official development assistance defunding trends continue, more than 7.9 million additional deaths could occur in low-income and middle-income countries by 2030.
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