🩺 #Yeast as a disease model: a screen in cardiolipin-deficient yeast identified ebselen as a mitochondrial rescue compound effective across seven fungal models of mitochondrial disease, patient fibroblasts, cardiomyocytes and mice
🧬 #YeastResearch 🧪 #SGD 🔬

www.yeastgenome.org/reference/S1...

📊 Different methods for profiling #Yeast cell walls capture different things. Scatter-based flow cytometry tracks mannan abundance; lectin fluorescence reflects surface composition. Approaches are complementary rather than interchangeable
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🖖 What drives replicative aging in #Yeast? An @oregonstate.edu 🦫 screen found 132 variant genes & 60 differentially expressed genes with little overlap, suggesting longevity is governed by many genes through diverse mechanisms

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

✂️ A nonessential #Yeast spliceosome factor w/conserved domain touching the catalytic core turns out to matter more than expected: Cwc15 stabilizes active site & facilitates structural transitions, implications for splice site proofreading
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🧘 #Yeast RPL22 pre-mRNA acts as its own regulator. The intron toggles between 2 competing structures: one blocks splicing, one permits it. Rising Rpl22 levels shift the balance toward inhibition, creating a protein-responsive RNA switch

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

♻️ #Yeast Acs2 generates acetyl-CoA locally at chromatin, while its mammalian ortholog ACSS2 also recaptures acetate from histone deacetylation at promoters. This acetate recycling loop couples metabolism ↔️ chromatin state across species
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🏋️ Not all #Yeast strains handle acetic acid equally. Respiratory capacity and carbon flux determine survival under acid stress, and two S. cerevisiae strains show strikingly different responses with implications for strain engineering

🧬 #YeastResearch 🧪 #SGD 🔬

www.yeastgenome.org/reference/S1...

FYI: Researchers in Iran Raise Yeast Biomass to 100.04g/L by Optimizing Culture Conditions #YeastResearch #Biomass #SustainableLab #Fermentation #Microbiology

🧲 How does #Yeast CAF-1 find the replication fork to deposit histones? Via PCNA, using not 1 but 2 PIP motifs. The newly found PIP1β makes atypical extended contacts w/second PCNA subunit; disrupting both motifs abolishes CAF-1 function
🧬 #YeastResearch 🧪 #SGD 🔬

www.yeastgenome.org/reference/S1...

Grateful to receive the @femsjournals.bsky.social Yeast Research Poster Prize at #SMYTE2026 for my work on sterol dynamics at the yeast plasma membrane! Many thanks to Roland and everyone at ICDI for their guidance and support—and to all who stopped by for very cool discussions.
#yeastresearch

🗑️ #Yeast nuclear ubiquitin ligase Uls2 has surprising side job: tagging cytosolic proteins for degradation. Orphaned/ oxidatively damaged proteins aggregate in nucleus & become SUMO-dependent substrate ➡️ = compartment-spanning QC pathway
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🫧 Autophagosome membranes don't just grow by lipid transfer. #Yeast cryo-ET shows vesicles clustering around and fusing with the phagophore rim during expansion, a contribution that was previously attributed only to the nucleation stage

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Great time at #PYFF9 in Valencia! 🧫🍻 Sharing the latest research from #FunGIALab, discussing yeast biology, fermentation and biotechnology, and reconnecting with colleagues made for a fantastic meeting. Excellent science, inspiring discussions, and great people. #YeastResearch #FungalBiotechnology

Researchers in Iran Raise Yeast Biomass to 100.04g/L by Optimizing Culture Conditions #YeastResearch #Biomass #SustainableAgriculture #FoodScience #Biotechnology

Grapevine Yeasts Reduced a White Rot Pathogen by 83% in Laboratory Tests #Grapevine #YeastResearch #PlantPathology #FungusControl #WineScience

⛓️‍💥 In #Yeast a broken helicase can be worse than no helicase. Inactive Hrq1 binds DNA but can't unwind it= 🙅 inter-strand crosslink repair. ➡️ Sheds light on how partial LoF mutations in human RECQL4 may similarly disrupt genome stability.
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

✂️ The spliceosome has to shed Dib1 before it can start cutting RNA. New #Yeast research shows Dib1's C-terminal tail is what keeps it docked near the catalytic core via Prp8 and Prp31, and losing that tail is enough to kill the cell.

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🛟 When DNA breaks in #Yeast, Tel1 phosphorylates Rad9, driving its self-assembly to hold broken ends together & steer repair toward homologous recombination. A Tel1 FAT-domain variant reveals this axis by rescuing end-tethering defects

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

📈 #Yeast Dhh1 (human DDX6) bridges deadenylation and decapping in mRNA decay, but how it's activated was unclear. Edc3 and Not1 tune its ATPase activity through distinct mechanisms, cooperating for a 200-fold boost

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

🕳️ #Yeast CCP isn't just an H₂O₂ scavenger, it's a sensor. When H₂O₂ spikes in respiring mitochondria, hole hopping oxidizes H175, releasing the heme to activate catalase A and keep the ETC running efficiently.
Also, oxene≠ox...or does it?
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...