Helios is critical for Treg effector differentiation in #adipose #autoimmunity. New study from Angela M. Thornton, Ethan M. Shevach and colleagues @niaidnews.bsky.social:
rupress.org/jem/article/...
@jem.org
@jem.orgHelios is critical for Treg effector differentiation in #adipose #autoimmunity. New study from Angela M. Thornton, Ethan M. Shevach and colleagues @niaidnews.bsky.social:
rupress.org/jem/article/...
@genesndiseases.bsky.socialCould reprogramming #Tregs limit #RadiationInducedLungInjury?
This study identifies the METTL3/miR-223-3p/Lif axis as a regulator of Treg differentiation and #fibrosis, revealing a potential therapeutic target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@rupress.orgIn @jem.org, Thornton et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@jem.orgThornton, Shevach et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@fds3rd.bsky.socialWhat Are #Tregs? Explaining 2025’s #Nobel Prize-Winning Research
#LifeSciences #Immunology
@fds.wsocial.euWhat Are #Tregs? Explaining 2025’s #Nobel Prize-Winning Research
#LifeSciences #Immunology