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Among men in 2 cohort studies, hematologic loss of chromosome Y was associated with higher risk of incident #AbdominalAorticAneurysm but not #ThoracicAorticAneurysm. ja.ma/4d5PMcY

Loss of Y chromosome is associated with ⬆️risk of #AAA #AbdominalAorticAneurysm but Not #TAA #ThoracicAorticAneurysm

LOY was measured in blood cells

#UKBiobank
N=221k, 13.5 y f/up

Phototype variation reveals systemic biology.
#SunburnSusceptibility and #ThoracicAorticAneurysm are driven by pigmentation and tanning response genetics, with exploratory links to matrix turnover, intracellular trafficking, & vascular remodeling.
#CVIA #OpenAccess: cvia-journal.org/genetic-driv...

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Among men in 2 cohort studies, hematologic loss of chromosome Y was associated with higher risk of incident #AbdominalAorticAneurysm but not #ThoracicAorticAneurysm. ja.ma/4d5PMcY

Loss of Y chromosome is associated with ⬆️risk of #AAA #AbdominalAorticAneurysm but Not #TAA #ThoracicAorticAneurysm

LOY was measured in blood cells

#UKBiobank
N=221k, 13.5 y f/up