How does #HCC withstand #OxidativeStress during therapy?

This study identifies a HIF1α–KLF4–hemoglobin axis that scavenges ROS and promotes sorafenib resistance, revealing a targetable redox adaptation.

#STTT #OpenAccess: doi.org/10.1038/s413...

#TumorHypoxia #TherapyResistance #CancerBiology