Monospecific antibodies reveal reduction of granulins in #FrontotemporalDementia caused by GRN mutations

Paola Merino, Ludmilla Troiano Araujo, Anarmaa Mendsaikhan...Thomas Kukar @kukarlab.bsky.social #TDP43 #Progranulin #LysosomalStorageDisorder

link.springer.com/article/10.1...

Nucleoporin 50 rescues hallmarks of #TDP43 proteinopathy in #ALS/FTD disease models

Courtney L. Smith, Bilal Khalil, Alyssa C. Walker... Wilfried Rossoll @rossolllab.bsky.social @mayoclinic.org #FrontotemporalDementia

link.springer.com/article/10.1...

In vivo detection of pathologic α- #synuclein and #TDP43 in the skin and olfactory mucosa of a patient with #Parkinsons disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation

Paola Caroppo, Vittoria Aprea...Grazia Devigili

link.springer.com/article/10.1...

As part of our inaugural review series!

Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?

Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein

link.springer.com/article/10.1...

Just Published !

#TDP43 #ALS #neurodegeneration #yeast #endoplasmicreticulum

onlinelibrary.wiley.com/doi/10.1111/...