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@sigtrans-sttt.bsky.socialSep 21, 2026, 10:00 AM

Targeting ROCK2 may offer a therapeutic approach for chronic graft-versus-host disease (#cGVHD). This phase Ib study finds encouraging responses and a manageable safety profile with TDI01, a highly selective ROCK2 inhibitor.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Fibrosis #TCellImmunity

Novel highly selective ROCK2 inhibitor (TDI01) for the treatment of chronic graft-versus-host disease: a multicenter, open-label phase Ib/II study
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