In @jhumimmunity.org, Iglesias-Herrero et al longitudinally assess JAK-inhibitor treatment response in two patients w/ #STAT1 gain-of-function & show that it induces rapid but incomplete immune reconstitution w/ increased TCR diversity & reversal of monocyte hyperinflammation doi.org/10.70962/jhi...

Iglesias-Herrero, Schrijvers et al. longitudinally assess JAK-inhibitor treatment response in two patients w/ #STAT1 gain-of-function & show that it induces rapid but incomplete immune reconstitution, w/ increased TCR diversity and reversal of monocyte hyperinflammation. rupress.org/jhi/article/...