🧬 From TCR signalling to gene therapy and CAR-T cells!

Our final session at #SFB1160 brought together Claire Booth, Susana Minguet, Valeria Melendez, Anna-Sophia Baur & Chenqi Xu — with patient stories, new therapeutic ideas and even a friendship born from scientific rivalry.

#IMPATH

🦠 Antiviral immunity is anything but straightforward!

From CD8 T cells and interferon autoantibodies to EBV-associated disease and colourful MxA imaging — Session VI at #SFB1160 covered a lot of ground.

Thanks to Daniel Pinschewer, Jakob Ankerhold, Sylvain Latour & Armin Mauerer!

🧬 Why does the same genetic variant cause disease in some people but not others?

Dusan Bogunovic’s #SFB1160 explored monoallelic expression, incomplete penetrance & the intriguing possibility that genetic variants may have different effects depending on their context.

A lively discussion followed!

🔬 “You are what you eat” counts even for immuncells!

From cDC1 cross-presentation and macrophage plasticity to type I interferons and γδ CAR-T cells, Session V at #SFB1160 covered quite some ground!

Thanks to Caetano Reis e Sousa, Sebastian Baach, Lidia Bosurgi, Andreas Wack & Marina Zintchenko!

🔬 Immune cells don’t work in isolation!

Session IV at #SFB1160 took us from Mauro Gaya’s mucosal B cells and Jakob Arnold’s γδ T cells to Naresha Saligrama’s Ly49⁺ T cells and Jovana Cupovic’s tissue-supporting stromal cells.

#IMPATH

🔬 What makes immune memory last?

Session III at #SFB1160 explored T cell fate decisions, stem-like renewal in T and NK cells, and how checkpoint inhibition shapes memory after hepatitis E infection.

Thanks to Laurence Kupferschmid, Veit Buchholz & Michelle Maas!

#IMPATH

Day 2 at #SFB1160 began with Stephan Ehl’s IMPATH Lecture!

From the “(hi)Story of IMPATH” to fHLH and the IMPATH paradox: impaired immunity can also drive excessive inflammation.

#IMPATH #Immunology

☔ Rainy in Freiburg, but plenty of lively conversations inside!

Our #SFB1160 poster sessions and coffee breaks are a chance to share research, ask questions and connect with fellow scientists.

Science happens between the talks, too. ☕🔬

#IMPATH

🔬 Session II at #SFB1160: Autoimmunity & tolerance.

Peter Savage explored regulatory T cell fate and function, Marc Schmidt-Supprian discussed T cell control of B cell hyperreactivity, and Christoph König & Tony Yao presented work on FAS-related T cell regulation.

#IMPATH

👌🏼 more from Session I at #SFB1160 about monogenic immune dysregulation!

Lars Gerullat presented work on PLCG2 haploinsufficiency, Sophie Hambleton discussed insights from inborn errors of immunity, and Faris Zeco explored the potential role of ACTN1 variants in autoimmunity.

#IMPATH

🧬 One gene, many faces!

With a last-minute title change and a smile, Frédéric Rieux-Laucat opened #SFB1160!

His key message: Monogenic variants can cause very different immune disorders, even within families. Identifying them may open doors to targeted therapies.

#IMPATH

🎉 The #SFB1160 Symposium starts today!

We’re excited to welcome an outstanding line-up of international speakers to Freiburg!

Take a look at who’s joining us for three days of immunology research and scientific exchange! 👇

#IMPATH #Immunology

📢 Final registration day! Join us at #SFB1160 #Symposium “IMPAIRED IMMUNITY: From Immunopathology to Immune Reconstitution”.
Date: October 8–10, 2026
Venue: KG I, #UniversityOfFreiburg
Program: www.sfb1160.uni-freiburg.de/symposium-20...
Be part of great #Immunology #Research #ScientificExchange