Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. #ScienceSignaling https://scim.ag/4zj9pqt

A preclinical #ScienceSignaling analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to oxphos curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. https://scim.ag/4yzeCub

Scientists target a G protein regulator to combat neuropathic pain, a study in mice shows how metabolically reprograming disease-linked T cells can calm inflammation in inflammatory bowel disease, and more in the new issue of #ScienceSignaling. https://scim.ag/4AS62bx

Researchers have constructed a map of how light remodels patterns in a process called phosphorylation in the eye of the fruit fly, illuminating the core #biochemistry that enables these flies to adapt to oscillating light and dim conditions. #ScienceSignaling https://scim.ag/4jmYN5a

A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling.

scim.ag/4xTKRTQ

A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology.

Learn more: scim.ag/3Vjodqq

A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology. https://scim.ag/4dCF2ms

A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling. https://scim.ag/3VdwiwU

New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. https://scim.ag/3V1ilCa

A new proximity labeling and biophysical analysis shows that the protein Girdin-L is an unexpected ligand of the PDZ domain of the Dishevelled protein and plays an important role in promoting the breakdown of primary cilia on cells. #ScienceSignaling https://scim.ag/47koCeN

The new issue of #ScienceSignaling is out!

Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. https://scim.ag/4dSEzN0

In a new Focus in #ScienceSignaling, scientists examine pioneering results from a recent paper in #ScienceMagazine, which decoded how #viruses co-opt the ubiquitin-proteasome system in host cells to interfere with innate immune defenses. https://scim.ag/46ViQAb

Using advanced protein tagging techniques, researchers have made new discoveries about the assorted members of a protein interactome that guides signaling in cells in the lymphatic system, which could inform novel therapeutics.

Discover more in #ScienceSignaling: scim.ag/4gQZty9

Using advanced protein tagging techniques, researchers have made new discoveries about the assorted members of a protein #interactome that guides signaling in cells in the #lymphatic system, which could inform novel therapeutics. #ScienceSignaling https://scim.ag/4hqlbJo

The new issue of #ScienceSignaling is out!

Proteomics identifies an unexpected member of the adrenomedullin receptor interactome in lymphatic endothelial cells, a new Focus explores a pioneering study in Science decoding how viruses co-opt host cells, and more. https://scim.ag/4As9k5k

A tumor’s specific #NRAS mutation could determine the best course for therapy in NRAS-mutant cancers, according to new work in #ScienceSignaling. https://scim.ag/3TmPDuQ

In a new #ScienceSignaling paper, scientists have found that the notorious pathogen C. difficile, the cause of many hospital-acquired infections, can detoxify bacitracin to colonize the gut. https://scim.ag/4cC5bBw

This week’s new issue of #ScienceSignaling has arrived!

https://scim.ag/4icvn9o

In a new #ScienceSignaling Review, researchers discuss recent structural and functional studies of aGPCR activation that suggest two main activation mechanisms for these receptors.

Learn more: https://scim.ag/4h5GMFZ