#RUNX2 helps bone-removing cells work. In mouse and cell studies, it activated a newly identified RNA, LncRNA-ROD, which bound QKI and protected Csf1r #mRNA from breakdown. Mice lacking this RNA showed less #bone resorption around teeth and delayed eruption.👇
www.nature.com/articles/s41...

What drives chondrocyte hypertrophy in #osteoarthritis?
This study identifies #POSTN as a regulator of #RUNX2-driven hypertrophy, with its suppression reducing cartilage damage, synovial inflammation and OA progression.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

This study identifies SCFJFK as an E3 ligase that mediates #RUNX2 degradation, and a reciprocal RUNX2–JFK feedback loop linking #Proteostasis to #Osteogenesis and the pathogenesis of #CleidocranialDysplasia. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...