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@sablesystems.bsky.socialOct 7, 2026, 5:01 PM

TOMORROW — the main program for the #AdiposeBiology #Conference kicks off in Montreal, Canada! Sable is a proud partner of this event.

Are you joining? If so, we'd love to chat with you, so come say hi!

buff.ly/9mANSYt

#Metabolism #Physiology #Adipose #Obesity #Respirometry #IndirectCalorimetry

@sablesystems.bsky.socialOct 1, 2026, 5:02 PM

Less than a week to go until the #AdiposeBiology #Conference kicks off in Montreal, Canada (Oct 7–9)!

We'll be there as a proud partner of this important event. 😁

buff.ly/8qNkkHR

#Metabolism #Physiology #Respirometry #IndirectCalorimetry #Obesity #Thermogenesis

@alicefrolov.bsky.socialSep 30, 2026, 5:00 PM

"Electron Transport Chain Capacity Erodes Complex-by-Complex with Age"

Subtitle: Simulated OXPHOS complex activity (% of young) across four age groups in skeletal muscle.

#OXPHOS #MitochondrialBioenergetics #Respirometry #MtDNA #SkeletalMuscleMetabolism #ElectronTransportChain #Bioenergetics

"Electron Transport Chain Capacity Erodes Complex-by-Complex with Age" Subtitle: Simulated OXPHOS complex activity (% of young) across four age groups in skeletal muscle. I am sharing a radial polar bar representation designed to communicate the differential, non-uniform decline of individual respiratory chain complexes with advancing age. Each angular segment of the "electron transport chain wheel" corresponds to one of the five OXPHOS complexes (CI: NADH:ubiquinone oxidoreductase; CII: succinate dehydrogenase; CIII: cytochrome bc1; CIV: cytochrome c oxidase; CV: F1Fo-ATP synthase), while radial extent encodes activity normalized to a young reference cohort (100%). Four concentric bands stratify the age groups, permitting rapid visual comparison of complex-specific trajectories. I want to emphasize that the underlying data are simulated. They are not derived from a primary cohort but are parameterized to reproduce trends repeatedly documented in the literature: the disproportionate vulnerability of Complexes I and IV, both of which incorporate mtDNA-encoded subunits and are therefore sensitive to the accumulation of somatic mtDNA deletions and point mutations, clonal expansion of mutant genomes, and impaired mitochondrial proteostasis. Complex II, being entirely nuclear-encoded, is rendered comparatively preserved, consistent with its frequent use as a normalization reference in respirometric and histochemical assays. The polar geometry was chosen deliberately to foreground the coupled, sequential architecture of the respiratory chain rather than to imply independence between complexes. Declining CI and CIII capacity constrains ubiquinone and cytochrome c redox cycling, with downstream consequences for proton-motive force generation and CV throughput. I welcome methodological critique, particularly regarding whether polar encoding introduces perceptual distortion of the radial magnitudes relative to a conventional Cartesian layout.
@sablesystems.bsky.socialSep 23, 2026, 5:03 PM

Join us at the #AdiposeBiology #Conference in 2 weeks! (Oct 7–9, Montreal, Canada)

Sable Systems is a proud partner of this exciting event. 😁

buff.ly/8qNkkHR

#Metabolism #Physiology #Respirometry #IndirectCalorimetry #Obesity #Thermogenesis

@sablesystems.bsky.socialSep 16, 2026, 5:30 PM

TOMORROW — the #ComparativePhysiology #Conference kicks off in Orlando, FL (Sep 17–21)!

Sable Systems is proud to sponsor this exciting event.

buff.ly/jMKC4Hp

#CPC2026 #Physiology #Respirometry #IndirectCalorimetry

@sablesystems.bsky.socialSep 16, 2026, 12:06 AM

Next week, the #ComparativePhysiology #Conference kicks off in Orlando, FL (Sep 17–21)!

The program covers research on #thermogenesis, #metabolism, #OxygenTransport, and much more besides.

Sable Systems is proud to sponsor this exciting event!

buff.ly/rBiZlp1

#CPC2026 #Physiology #Respirometry

@sablesystems.bsky.socialSep 7, 2026, 4:15 PM

The #AdiposeBiology #Conference is just 1 month away (Oct 7–9, Montreal, Canada) — we're looking forward to hearing about the latest findings from leading researchers in the field!

buff.ly/kklCziA

#Adipose #Obesity #Diabetes #IndirectCalorimetry #Respirometry #Metabolism #Physiology