9. High-level tumour #methylation of #BRCA1 and #RAD51C is required for #homologousrecombination deficiency in solid cancers - Xu et al doi.org/10.1093/narc.... Extends BRCA-network deficiency beyond sequence mutations to #epigeneticsilencing. 10/18

2. RAD51C breast cancer-identified variants with attenuated homologous recombination function... Ganesan et al.
doi.org/10.1093/narc... #RAD51C variants retain partial #HR yet disrupt replication and accumulate gaps; a subset sensitizes cells to combined #PARP1 and #ATR inhibition. 3/18