Can light power stressed #Mitochondria? Engineered mt-EcGAPR uses ambient light to enhance ATP production and reduce ROS, suppressing ER stress–ATF6–GSDMD-mediated #Pyroptosis and protecting retinal ganglion cells.

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#RetinalResearch #Neuroscience

📘Read in #JEV📘 Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy #tumorimmunotherapy #nanovesicles #checkpointblockade #pyroptosis isevjournals.onlinelibrary.wiley.com/doi/epdf/10....

Doxorubicin-treated #BreastCancer cells release exosomal miR-216a-5p that targets ITCH and activates TXNIP–NLRP3 signaling, revealing tumor–heart crosstalk that promotes cardiomyocyte #Pyroptosis and #CardiacInjury. @fudan-university.bsky.social

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Hepatic #Ischemia–reperfusion injury complicates liver surgery and transplantation.
Myeloid CD38 deficiency activates NAD+/SIRT1 signaling, promotes M2 macrophage polarization, and suppresses NLRP3-mediated #Pyroptosis and #Inflammation.

#STTT #OpenAccess: doi.org/10.1038/s413...