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@commsmed.nature.comSep 7, 2026, 7:20 AM

🚨 NEW research⚕️ 🩺

http://dlvr.it/TVMJvV

Byg et al. examine whether PRS for birthweight on adult cardiometabolic risk depend on phenotypic birthweight.

#PolygenicScores #Birthweight #CardiometabolicRisk

@jamapsychiatry.comSep 6, 2026, 2:36 PM

đź’ˇ Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening.

ja.ma/3UD8l1I

Diagram shows genomic testing informing prevention in psychiatry across mental illness stages. Before diagnostic consolidation, Primary prevention (Universal, Selective, Indicated) occurs. In the Zone of diagnostic uncertainty, PGS/rare variant testing inform diagnosis. After, Secondary/Tertiary prevention, pharmacogenomics guides treatment, & PGS/rare variant testing inform comorbidity.
@ocasapiens.bsky.socialSep 3, 2026, 12:38 PM

#GWAS
#polygenicscores

Meta-analysis to be taken with a large pinch of salt, imo.

Correlations are small, and "Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability."