#OxidativeStress -induced #microglial CD22 upregulation impairs #phagocytosis and exacerbates #Huntingtons disease
Yan Hua Lee, Jian Jing Siew, Chia-Wei Lee...Takashi Angata & Yijuang Chern
@molneurodegen.bsky.social
@molneurodegen.bsky.social#OxidativeStress -induced #microglial CD22 upregulation impairs #phagocytosis and exacerbates #Huntingtons disease
Yan Hua Lee, Jian Jing Siew, Chia-Wei Lee...Takashi Angata & Yijuang Chern
@jlbjournal.bsky.socialCarlos Blanco-Camarillo and colleagues report that #Obesity induces elevated numbers of low-density #Neutrophils (LDN), but these perform #Phagocytosis and #NETosis less efficiently than LDN from individuals with normal weight
@sigtrans-sttt.bsky.socialMitoferrin-1 sustains a NET histone–TLR9–IFNAR1 circuit that rewires neutrophil metabolism and promotes inflammatory tissue damage, revealing a strategy to restrain pathogenic responses while preserving #Phagocytosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Inflammation #ChronicInflammation
@sigtrans-sttt.bsky.socialBacteria-derived PAMPs can reprogram macrophage responses against #Cancer cells.
This study shows that PAMP-decorated cancer cells activate pattern recognition receptor pathways, enhancing macrophage #Phagocytosis and antitumor activity.