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@mitoworld.bsky.socialOct 6, 2026, 9:01 PM

How can #mtDNA change rapidly over just a few generations, and remain compatible with the independently inherited, evolving nuclear genome? Find out in @mitogene.bsky.social fascinating @natureportfolio.nature.com review:

lnkd.in/p/gPHJdCRs

#mitoscientists #mitochondria #mitochondrialevolution

@alicefrolov.bsky.socialSep 30, 2026, 5:00 PM

"Electron Transport Chain Capacity Erodes Complex-by-Complex with Age"

Subtitle: Simulated OXPHOS complex activity (% of young) across four age groups in skeletal muscle.

#OXPHOS #MitochondrialBioenergetics #Respirometry #MtDNA #SkeletalMuscleMetabolism #ElectronTransportChain #Bioenergetics

"Electron Transport Chain Capacity Erodes Complex-by-Complex with Age" Subtitle: Simulated OXPHOS complex activity (% of young) across four age groups in skeletal muscle. I am sharing a radial polar bar representation designed to communicate the differential, non-uniform decline of individual respiratory chain complexes with advancing age. Each angular segment of the "electron transport chain wheel" corresponds to one of the five OXPHOS complexes (CI: NADH:ubiquinone oxidoreductase; CII: succinate dehydrogenase; CIII: cytochrome bc1; CIV: cytochrome c oxidase; CV: F1Fo-ATP synthase), while radial extent encodes activity normalized to a young reference cohort (100%). Four concentric bands stratify the age groups, permitting rapid visual comparison of complex-specific trajectories. I want to emphasize that the underlying data are simulated. They are not derived from a primary cohort but are parameterized to reproduce trends repeatedly documented in the literature: the disproportionate vulnerability of Complexes I and IV, both of which incorporate mtDNA-encoded subunits and are therefore sensitive to the accumulation of somatic mtDNA deletions and point mutations, clonal expansion of mutant genomes, and impaired mitochondrial proteostasis. Complex II, being entirely nuclear-encoded, is rendered comparatively preserved, consistent with its frequent use as a normalization reference in respirometric and histochemical assays. The polar geometry was chosen deliberately to foreground the coupled, sequential architecture of the respiratory chain rather than to imply independence between complexes. Declining CI and CIII capacity constrains ubiquinone and cytochrome c redox cycling, with downstream consequences for proton-motive force generation and CV throughput. I welcome methodological critique, particularly regarding whether polar encoding introduces perceptual distortion of the radial magnitudes relative to a conventional Cartesian layout.
@mitoworld.bsky.socialSep 28, 2026, 5:19 PM

#Mitochondria & #aging #neurodegenerativedisease #kidneydisease & much more #mitochondrialdisease insights from @cvasilescu.bsky.social in this week's @biomednews.bsky.social curation. Check it out!

#mitoscientists #UMDF #mtDNA #mitochondrialtransplantation

@isogg.bsky.socialSep 22, 2026, 9:18 PM

“The Lost Descendants of Thomas Jefferson” #NewYorker #ThomasJefferson #SallyHemings #DNA #genetics #mtDNA #autosomalDNA #ISOGG www.newyorker.com/news/the-led...

@mitoworld.bsky.socialSep 22, 2026, 3:17 PM

An exciting advance for patients with #mitochondrialdisease as new drug gets fast tracked! See more below from Pretzel Therapeutics as they tackle #POLG #mitochondrialdysfunction :

lnkd.in/p/gftQnsCD

#mitocanda #UMDF #mitoscientists #mitochondria #mtDNA #mitochondrialtherapy

@mitoworld.bsky.socialSep 21, 2026, 1:45 PM

#Mitoscientists check out all things #mitochondria in health and disease in this week's highlights from @cvasilescu.bsky.social @biomednews.bsky.social - including #mtDNA diagnostics, targeted therapies for #mitochondrialdisease and more!

#neurologicaldisease #mitoneuro #mitocardio #mitometabolism

@alicefrolov.bsky.socialSep 20, 2026, 5:00 PM

Mitochondrial membrane potential heterogeneity with age

I am sharing a data visualization exploring how mitochondrial membrane potential (Δψm) declines.

#MitochondrialBioenergetics #TMRM #MembranePotential #Mitophagy #SingleCellHeterogeneity #OxidativePhosphorylation #MtDNA
#ProtonMotiveForce

Mitochondrial membrane potential heterogeneity with age I am sharing a data visualization exploring how mitochondrial membrane potential (Δψm) declines and becomes more dispersed across the lifespan. The figure, titled "Mitochondrial membrane potential collapses and disperses with age," presents single-cell TMRM (tetramethylrhodamine methyl ester) intensity across four age groups in three tissues. I want to emphasize at the outset that the underlying dataset is simulated; it is constructed to illustrate a trend that is well grounded in the existing literature rather than to report novel empirical measurements. The chart employs a faceted raincloud design, with each tissue occupying its own facet. Within each facet, the four age cohorts are represented by a combination of a half-density (violin) contour, jittered single-cell points, and an overlaid boxplot. This composite format was chosen deliberately to convey both central tendency and the full distributional structure, which is critical here because the phenomenon of interest is not only a shift in the mean but an expansion of intercellular variance. Two features are salient. First, median TMRM intensity declines monotonically with advancing age across all three tissues, consistent with progressive dissipation of the proton-motive force and diminished electron transport chain coupling efficiency. Second, and more importantly, the distributions broaden with age, indicating increasing cell-to-cell heterogeneity in Δψm. This dispersion is compatible with mosaic accumulation of mtDNA mutations, clonal expansion of dysfunctional mitochondrial populations, and stochastic failure of quality-control mechanisms such as mitophagy. I would welcome discussion regarding appropriate normalization strategies for TMRM intensity, particularly the non-quench versus quench mode distinction, and how these affect interpretation of the observed variance structure.
@mitoworld.bsky.socialSep 8, 2026, 9:32 PM

Another iconic #mitochondria illustration from Christian Frezza to accompany his @biomednews.bsky.social curation! Dig in to this week's publication highlights on #mtDNA #mitometabolism #mitoimmune interactions & #mitocardio research

biomed.news/bims-camemi/...
#mitoscientists #mitochondrialdisease