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@dmmjournal.bsky.socialSep 22, 2026, 12:02 PM

Michelle Curley & co establish #Drosophila and #MouseModels of spinal muscular atrophy X-linked 2 and identified regulated proteins that may contribute to disease pathogenesis

Check out the article for free in DMM: doi.org/10.1242/dmm....

UBA1 knockdown reduces protein ubiquitination in Drosophila melanogaster and mouse skeletal muscles but primarily affects the levels of a limited set of proteins (‘UBA1-sensitive proteins’) that rely on optimal UBA1 levels for their turnover and stability.
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