State-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB. New study from Toshiki Yamada, Erkan Karakas, and Jerod S. Denton @vanderbilt.edu:
rupress.org/jgp/article/...
@jgp.org
@jgp.orgState-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB. New study from Toshiki Yamada, Erkan Karakas, and Jerod S. Denton @vanderbilt.edu:
rupress.org/jgp/article/...
@jgp.orgYamada, Karakas, & Denton @vanderbilt.edu show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains rupress.org/jgp/article/...
#IonChannels #MolecularPharmacology
@jgp.orgTunable AMPA receptor function via recurrent #evolution of heterotetramers. New study from Yuhong Wang, Alexander Edwards, Jelena Baranovic, and Timothy Lynagh @msarscentre.bsky.social:
rupress.org/jgp/article/...
#MolecularPharmacology #MembraneTransport #Biochemistry #Biophysics #IonChannels