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@sigtrans-sttt.bsky.socialSep 23, 2026, 3:31 PM

Chromosomal instability can drive tumor evolution while creating exploitable dependencies. This review connects the sources and consequences of CIN with tolerance pathways, emerging diagnostics, and therapeutic vulnerabilities.

#STTT #OpenAccess: doi.org/10.1038/s413...

#MolecularOncology

@sigtrans-sttt.bsky.socialSep 23, 2026, 12:30 PM

Cell-cycle dysregulation may provide a therapeutic vulnerability in uterine #Leiomyosarcoma.

This study links CDK/cyclin–phospho-Rb signaling to uLMS and shows antitumor effects of CDK4/6 inhibition with abemaciclib.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerBiology #MolecularOncology

Inhibition of CDK/Cyclin-phospho-Rb signaling by amebaciclib may have an antitumor effect against uterine leiomyosarcoma