Have you seen this #openaccess Perspective in #Cytoskeleton? #Microtubule Destabilizing #Kinesins: A Historical Perspective and Thoughts for the Future. Check it out here: onlinelibrary.wiley.com/doi/full/10....

In summary, we provide the first structural model for CM1 autoinhibition, a key mechanism that helps spatially regulate #microtubule nucleation. We also highlight key evolutionary differences in CM1 binding mechanisms.

We previously showed that an upstream CM1 autoinhibition domain is required to prevent binding and activation of g-TuRCs by #Drosophila Centrosomin (Cnn) to avoid ectopic cytosolic #microtubule nucleation and major #cell and #developmental defects
rupress.org/jcb/article/...

Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...

In @jcborg, Elfarkouchi, Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...

Excited to share that our latest story on #microtubule conformation controlling cell #signaling is now out in NCB! We show that microtubule expansion by taxane chemotherapeutics releases microtubule bound GEF-H1 which in turn activates RhoA/ROCK signaling. ✨
www.nature.com/articles/s41...

#Embryo in Focus🔍

Eight-cell stage mouse embryo, 2 days after fertilization. Microtubules are shown in cyan & DNA in magenta, with one blastomere already dividing ahead of the others

👨‍🔬 Scientific artwork by Hongbin Jin from @monashuniversity.bsky.social, Australia.

#microtubule #bioart #sciart