We're just beginning to explore what personalized #miBrains can teach us about individual brain biology and disease. Follow along as we continue to learn more and share our findings from the Blanchard Lab.
@joelwblanchard.bsky.social
@joelwblanchard.bsky.socialWe're just beginning to explore what personalized #miBrains can teach us about individual brain biology and disease. Follow along as we continue to learn more and share our findings from the Blanchard Lab.
@joelwblanchard.bsky.socialOne of the most exciting applications of #miBrains in the Blanchard Lab is the prospect of personalized medicine.
Because miBrains start from human cells, they can be engineered to match an individual donor's genetic profile – starting from something as simple as a skin biopsy.
@joelwblanchard.bsky.socialSpecial shoutout to first author Braxton Schuldt for leading this work as part of his PhD, & congratulations to our entire team here @scbrmmountsinai.bsky.social.
Excited to build on these findings and see what else we can uncover with #miBrains.
Read the full paper: www.cell.com/cell/abstrac...
@joelwblanchard.bsky.socialTo investigate the mechanisms driving these changes, we leveraged #miBrains, our 3D multicellular human brain tissue model, and found that APOE4 expression in mural cells was both necessary and sufficient to drive pericyte loss and myofibroblast accumulation.
@joelwblanchard.bsky.socialSpecial shoutout to first author Braxton Schuldt for leading this work as part of his PhD, & congratulations to our entire team here @scbrmmountsinai.bsky.social.
Excited to build on these findings and see what else we can uncover with #miBrains.
Read the full paper: www.cell.com/cell/abstrac...
@joelwblanchard.bsky.socialTo investigate the mechanisms driving these changes, we leveraged #miBrains, our 3D multicellular human brain tissue model, and found that APOE4 expression in mural cells was both necessary and sufficient to drive pericyte loss and myofibroblast accumulation.