Magic Methyl Effect explained!

The quiz answer was TRUE✅ A single #methyl group added by a #methyltransferase can dramatically alter a molecule’s activity, sometimes boosting a drug’s performance. These enzymes also play roles in gene regulation and metabolism.

👉 https://loom.ly/U5WVje4

Here you can see a cryoEM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome (PDB code: 9Y4P)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #dna #genome #epigenetics #methylation #methyltransferase #nucleosome

Researchers reported the findings in Horticulture Research. The work focuses on a previously uncharacterized citrus methylation step.
#polymethoxyflavones #methyltransferase
Details: doi.org/10.1093/hr/uhag128