@sigtrans-sttt.bsky.socialHow does macrophage zinc accumulation worsen #MASLD progression?
Macrophage zinc trapping activates IRE1α–XBP1s signaling, promoting IL-1β-driven #MetabolicReprogramming and lipid transfer to hepatocytes, driving liver inflammation.
@mapjournals.bsky.social#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
@sigtrans-sttt.bsky.socialMyeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.
