KEM 8.2
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by Post-Exertional Malaise (PEM), a delayed exacerbation of symptoms after physical, cognitive, emotional, or autonomic challenge.
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@unordnung.net@unordnung.netNew paper: The Kinetic Elasticity Model proposes that PEM may emerge from slow GPCR desensitization/recovery kinetics - not simply from energy failure. Different upstream phenotypes may converge on a shared signaling bottleneck.
doi.org/10.5281/zeno...