🎯 Benzoxazine–purine #hybrids: two compounds, two #mechanisms! #Compound 12 → pyroptosis-like death via HER2/JNK1 #inhibition. Compound 9 → kinase-independent apoptosis. Both with good ADMET profiles.

📌 www.mdpi.com/1999-4923/17...
#Anticancer #DrugDiscovery #MedicinalChemistry

Atomic-scale diamond finishing depends on balancing material removal with #surfaceintegrity. This review examines multi-physical field coupling polishing and the #mechanisms enabling ultra-smooth, damage-free surfaces.

#IJEM #OpenAccess: doi.org/10.1088/2631...

#MultiPhysics #Nanomanufacturing

Congratulations to Drs. Ibáñez-Sandín and Rodríguez del Río on organizing the 10th edition of PACI (Complex #Allergic #Pathology in #Children).

I’m grateful for the opportunity to discuss the #immunological #mechanisms of oral #tolerance in #homeostasis and #disease.