@mrclmb.ac.ukHow does neurodegeneration spread across the brain? 🧠
@sjorsscheres.bsky.social, Michel Goedert & Masata Hasegawa’s groups have demonstrated that human misfolded tau filaments act as a molecular template for prion-like propagation in the mouse brain.
@mrclmb.ac.ukHow do cells remove abnormal glycogen?
Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy.
https://mrclmb.ac.uk/news-events/articles/how-cells-clear-dysfunctional-glycogen/
#LMBResearch
@mrclmb.ac.uk🧠🦠 How can infection in the gut affect the brain?
Menna Clatworthy’s group in the University of Cambridge’s Molecular Immunity Unit at the LMB have identified an immune link between the gut & the brain that protects the brain from future infection.
@mrclmb.ac.ukThis was a large project, requiring mapping 166700+ neurons, involving a large, international team, including @janelia-flyem.bsky.social Google Research @camzoology.bsky.social with @beckett14.bsky.social Philipp Schlegel @stuartberg.bsky.social @mmcosta.bsky.social & many others.
#LMBResearch 2/2
@mrclmb.ac.ukThe complete #connectome of the adult Drosophila male CNS has allowed researchers, inc @jefferis.bsky.social’s group, to compare male & female brains at synaptic-resolution for the first time.
Read more here: mrclmb.ac.uk/news-events/...
#LMBResearch 1/2