Pathogenic #KIF1A variants differentially disrupt axonal trafficking and impede synaptic development. New study from Jayne Aiken @aikenlab.bsky.social, Erika Holzbaur @erikaholzbaur.bsky.social and colleagues @upenn.edu:
rupress.org/jcb/article/...

#Cytoskeleton #Disease #Neuroscience #Trafficking

Using iPSC-derived human #neurons gene-edited to express pathogenic #KIF1A variants, @aikenlab.bsky.social, @erikaholzbaur.bsky.social et al. demonstrate that distinct alterations in KIF1A motor function disrupt synaptic development through divergent cellular mechanisms rupress.org/jcb/article/...

In @jcb.org: Using iPSC-derived human #neurons gene-edited to express pathogenic #KIF1A variants, @aikenlab.bsky.social et al. demonstrate that distinct alterations in KIF1A motor function disrupt synaptic development through divergent cellular mechanisms. rupress.org/jcb/article/...